Auflistung nach Autor/Autorin "Holm, Rene"
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Antibiotic Resistance: The Need For a Global Strategy
(2016)Journal of Pharmaceutical SciencesThe development of antibiotic resistance is a major problem for mankind and results in fatal consequences on a daily basis across the globe. There are a no. of reasons for this situation including increasing globalization ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs – a PEARRL review
(2018-07)Journal of Pharmacy and PharmacologyObjectives Solubility parameters have been used for decades in various scientific fields including pharmaceutics. It is, however, still a field of active research both on a conceptual and experimental level. This work ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Approaches to increase mechanistic understanding and aid in the selection of precipitation inhibitors for supersaturating formulations – a PEARRL review
(2018-05)Journal of Pharmacy and PharmacologyObjectives Supersaturating formulations hold great promise for delivery of poorly soluble active pharmaceutical ingredients (APIs). To profit from supersaturating formulations, precipitation is hindered with precipitation ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Artificial neural networks to predict the apparent degree of supersaturation in supersaturated lipid-based formulations. A pilot study
(2021-09-05)pharmaceuticsIn response to the increasing application of machine learning (ML) across many facets of pharmaceutical development, this pilot study investigated if ML, using artificial neural networks (ANNs), could predict the apparent ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Exploring precipitation inhibitors to improve in vivo absorption of cinnarizine from supersaturated lipid-based drug delivery systems
(2021-04-01)European Journal of Pharmaceutical SciencesSupersaturated lipid-based drug delivery systems are increasingly being explored as a bio-enabling formulation approach, particularly in preclinical evaluation of poorlywater-soluble drugs. While increasing the drug load ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
In Silico, In Vitro, and In Vivo evaluation of precipitation inhibitors in supersaturated lipid-based formulations of venetoclax
(2021-04-23)Molecular PharmaceuticsThe concept of using precipitation inhibitors (PIs) to sustain supersaturation is well established for amorphous formulations but less in the case of lipid-based formulations (LBF). This study applied a systematic in ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
In Vivo Performance of Innovative Polyelectrolyte Matrices for Hot Melt Extrusion of Amorphous Drug Systems
(2020)Molecular PharmaceuticsHot melt extrusion of amorphous systems has become a pivotal technology to cope with challenges of poorly water-soluble drugs. Previous research showed that small molecular additives with targeted molecular interactions ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Lipophilic salts and lipid-based formulations for bridging the food effect gap of venetoclax
(2022-01)Pharmaceutics, Drug Delivery and Pharmaceutical TechnologyLipid based formulations (LBF) have shown to overcome food dependent bioavailability for some poorly water-soluble drugs. However, the utility of LBFs can be limited by low dose loading due to a low drug solubility in LBF ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Lipophilicity and hydrophobicity considerations in bio-enabling oral formulations approaches | a PEARRL review
(2019-04)Journal of Pharmacy and Pharmacology01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Lipophilicity and hydrophobicity considerations in bio‐enabling oral formulations approaches – a PEARRL review
(2018-08)Journal of Pharmacy and PharmacologyObjectives This review highlights aspects of drug hydrophobicity and lipophilicity as determinants of different oral formulation approaches with specific focus on enabling formulation technologies. An overview is provided ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Methodology of oral formulation selection in the pharmaceutical industry
(2016-05-25)European Journal of Pharmaceutical SciencesPharmaceutical formulations have to fulfil various requirements with respect to their intended use, either in the development phase or as a commercial product. New drug candidates with their specific properties confront ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Modified Polymer Matrix in Pharmaceutical Hot Melt Extrusion by Molecular Interactions with a Carboxylic Coformer
(2019)Molecular PharmaceuticsHot melt extrusion (HME) has become an essential technology to cope with an increasing number of poorly soluble drug candidates. However, there is only a limited choice of pharmaceutical polymers for obtaining suitable ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Pharmaceutical excipients — quality, regulatory and biopharmaceutical considerations
(2016)European Journal of Pharmaceutical Sciences01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Rational selection of bio-enabling oral drug formulations. A PEARRL commentary
(2021-05)Journal of Pharmaceutical SciencesNew drug candidates often require bio-enabling formation technologies such as lipid-based formulations, solid dispersions, or nanosized drug formulations. Development of such more sophisticated delivery systems generally ...01 - Zeitschriftenartikel, Journalartikel oder Magazin
