Auflistung nach Autor/Autorin "Messner, Catherine"
Anzeige der Einträge 1-9 von 9
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3D human liver microtissues vs. 2D monolayer culture as an in vitro tool for compound testing
(2018-10)06 - Präsentation -
Assessment of fibrotic pathways induced by environmental chemicals using 3D-human liver microtissue model
(2020-12-30)Environmental ResearchExposure to environmental chemicals, particularly those with persistent and bioaccumulative properties have been linked to liver diseases. Induction of fibrotic pathways is considered as a pre-requirement of chemical ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Evaluation of dioxin induced transcriptomic responses in a 3D human liver microtissue model
(2022)Environmental ResearchThree-dimensional human liver microtissue model provides a promising method for predicting the human hepatotoxicity of environmental chemicals. However, the dynamics of transcriptional responses of 3D human liver microtissue ...01A - Beitrag in wissenschaftlicher Zeitschrift -
Exosomal microRNAs Release as a Sensitive Marker for Drug-Induced Liver Injury In Vitro
(2020-09-16)Applied In Vitro Toxicology01 - Zeitschriftenartikel, Journalartikel oder Magazin -
How to Foster ‘New Approach Methodology’ Toxicologists
(2022-02-18)Alternatives to Laboratory AnimalsThe need to reduce, refine and replace animal experimentation has led to a boom in the establishment of new approach methodologies (NAMs). This promising trend brings the hope that the replacement of animals by using NAMs ...01A - Beitrag in wissenschaftlicher Zeitschrift -
Identification of miR-199a-5p, miR-214-3p and miR-99b-5p as fibrosis-specific extracellular biomarkers and promoters of HSC activation
(2021)International Journal of Molecular SciencesLiver fibrosis is characterized by the accumulation of extracellular matrix (ECM) resulting in the formation of fibrous scars. In the clinic, liver biopsies are the standard diagnostic method despite the potential for ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Methotrexate-induced liver injury is associated with oxidative stress, impaired mitochondrial respiration, and endoplasmic reticulum stress in vitro
(2022-12-01)International Journal of Molecular SciencesLow-dose methotrexate (MTX) is a standard therapy for rheumatoid arthritis due to its low cost and efficacy. Despite these benefits, MTX has been reported to cause chronic drug-induced liver injury, namely liver fibrosis. ...01A - Beitrag in wissenschaftlicher Zeitschrift -
Single Cell Gene Expression analysis in a 3D microtissue liver model reveals cell type-specific responses to pro-fibrotic TGF-β1 stimulation
(2021-04-22)International Journal of Molecular Sciences3D cell culture systems are widely used to study disease mechanisms and therapeutic interventions. Multicellular liver microtissues (MTs) comprising HepaRG, hTERT-HSC and THP-1 maintain multicellular interactions and ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
The role of bile salts in cholestatic injury and fibrosis using a human 3D in vitro model
(2018-11)06 - Präsentation
