Tailoring a solvent-assisted method for solid-supported hybrid lipid–polymer membranes
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Authors
Di Leone, Stefano
Kyropoulou, Myrto
Köchlin, Julian
Wehr, Riccardo
Meier, Wolfgang P.
Palivan, Cornelia G.
Author (Corporation)
Publication date
17.05.2022
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Type
01A - Journal article
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Parent work
Langmuir
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DOI of the original publication
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Volume
38
Issue / Number
21
Pages / Duration
6561-6570
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Publisher / Publishing institution
American Chemical Society
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Abstract
Combining amphiphilic block copolymers and phospholipids opens new opportunities for the preparation of artificial membranes. The chemical versatility and mechanical robustness of polymers together with the fluidity and biocompatibility of lipids afford hybrid membranes with unique properties that are of great interest in the field of bioengineering. Owing to its straightforwardness, the solvent-assisted method (SA) is particularly attractive for obtaining solid-supported membranes. While the SA method was first developed for lipids and very recently extended to amphiphilic block copolymers, its potential to develop hybrid membranes has not yet been explored. Here, we tailor the SA method to prepare solid-supported polymer–lipid hybrid membranes by combining a small library of amphiphilic diblock copolymers poly(dimethyl siloxane)–poly(2-methyl-2-oxazoline) and poly(butylene oxide)-block–poly(glycidol) with phospholipids commonly found in cell membranes including 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine, sphingomyelin, and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(glutaryl). The optimization of the conditions under which the SA method was applied allowed for the formation of hybrid polymer–lipid solid-supported membranes. The real-time formation and morphology of these hybrid membranes were evaluated using a combination of quartz crystal microbalance and atomic force microscopy. Depending on the type of polymer–lipid combination, significant differences in membrane coverage, formation of domains, and quality of membranes were obtained. The use of the SA method for a rapid and controlled formation of solid-supported hybrid membranes provides the basis for developing customized artificial hybrid membranes.
Keywords
Polymers, Copolymers, Hydrophobicity, Lipids, Membranes
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ISBN
ISSN
0743-7463
1520-5827
1520-5827
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Hybrid
License
Citation
Di Leone, S., Kyropoulou, M., Köchlin, J., Wehr, R., Meier, W. P., & Palivan, C. G. (2022). Tailoring a solvent-assisted method for solid-supported hybrid lipid–polymer membranes. Langmuir, 38(21), 6561–6570. https://doi.org/10.1021/acs.langmuir.2c00204