IRF: Institutional Repository FHNW
Welcome to the publication and research database of the FHNW University of Applied Sciences and Arts Northwestern Switzerland.
The institutional repository contains publications, projects and student theses.
Further information can be found in the IRF manual (available in German).
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Recently added
Unterrichtliche Reflexionsstopps. Rekonstruktionen zu Interaktionen zwischen Klassenlehrpersonen und Schulischen Heilpädagog:innen in kooperativen Unterrichtssettings
(Stiftung Schweizer Zentrum für Heil- und Sonderpädagogik, 11.02.2025) Papke, Katharina
01A - Beitrag in wissenschaftlicher Zeitschrift
Modulating the electronic structure of Mn promotes singlet oxygen generation from electrochemical oxidation of H₂O via O-O coupling
(Elsevier, 12/2024) Chen, Hao; Hou, Zhiang; Yue, Jinzhu; Wang, Jinnan; Wang, Yi; Li, Aimin; Corvini, Philippe
Selectively catalytic conversion H₂O into singlet oxygen (¹O₂) without additional oxidants is considered as an economic-efficient method for organic pollutants degradation. However, H₂O are more consistent with the spin state of ¹O₂ than common oxygen (O₂), retarding the kinetics of spin transition-induced reaction between O₂ and ¹O₂. Herein, we report an unprecedented ¹O₂ mediated electrocatalytic oxidation process, which allows O–O coupling for ¹O₂ evolution from H₂O over CrMn@C anode. The electron occupancy (eg) of CrMn@C (0.89) is very close to the optimal eg (0.95) of manganese-based materials reported in the literature, which facilitates the activation of H₂O on surface. Mn(Mn0.193Cr1.808)O₄-Mn in CrMn@C electrode significantly promotes the activation of H₂O to produce *O, followed by coupling of *O at adjacent sites to produce *OO, which further spontaneously forms ¹O₂. And H₂¹⁸O isotope experiments provide direct evidence for the production of ¹O₂ directly from H₂O. Consequently, the production of ¹O₂ is enhanced with the yield of 785.6 μmol·L⁻¹. Such ¹O₂-dominated electrocatalytic oxidation system can achieve efficient removal of electron-rich pollutant (bisphenol A) and improve the biodegradability of pharmaceutical wastewater (from 0.17 to 0.39).
01A - Beitrag in wissenschaftlicher Zeitschrift
Comparison of protein-like model particles fabricated by micro 3D printing to established standard particles
(Elsevier, 08/2024) Amara, Ilias; Germershaus, Oliver; Lentes, Christopher; Sass, Steffen; Youmto, Stephany Mamdjo; Stracke, Jan Olaf; Clemens-Hemmelmann, Mirjam; Assfalg, Anacelia
Innovative analytical instruments and development of new methods has provided a better understanding of protein particle formation in biopharmaceuticals but have also challenged the ability to obtain reproducible and reliable measurements. The need for protein-like particle standards mimicking the irregular shape, translucent nature and near-to-neutral buoyancy of protein particles remained one of the hot topics in the field of particle detection and characterization in biopharmaceutical formulations. An innovative protein-like particle model has been developed using two photo polymerization (2PP) printing allowing to fabricate irregularly shaped particles with similar properties as protein particles at precise size of 50 µm and 150 µm, representative of subvisible particles and visible particles, respectively.
A study was conducted to compare the morphological, physical, and optical properties of artificially generated protein particles, polystyrene spheres, ETFE, and SU-8 particle standards, along with newly developed protein-like model particles manufactured using 2PP printing.
Our results suggest that 2PP printing can be used to produce protein-like particle standards that might facilitate harmonization and standardization of subvisible and visible protein particle characterization across laboratories and organizations.
01A - Beitrag in wissenschaftlicher Zeitschrift
Technical note: development of a simulation framework, enabling the investigation of locally tuned single energy proton radiography
(IOP Publishing, 07.02.2024) Lundberg, Måns; Meijers, Arturs; Souris, Kevin; Deffet, Sylvain; Weber, Damien C; Lomax, Antony; Knopf, Antje
Range uncertainties remain a limitation for the confined dose distribution that proton therapy can offer. The uncertainty stems from the ambiguity when translating CT Hounsfield Units (HU) into proton stopping powers. Proton Radiography (PR) can be used to verify the proton range. Specifically, PR can be used as a quality-control tool for CBCT-based synthetic CTs. An essential part of the work illustrating the potential of PR has been conducted using multi-layer ionization chamber (MLIC) detectors and mono-energetic PR. Due to the dimensions of commercially available MLICs, clinical adoption is cumbersome. Here, we present a simulation framework exploring locally-tuned single energy (LTSE) proton radiography and corresponding potential compact PR detector designs. Based on a planning CT data set, the presented framework models the water equivalent thickness. Subsequently, it analyses the proton energies required to pass through the geometry within a defined ROI. In the final step, an LTSE PR is simulated using the MCsquare Monte Carlo code. In an anatomical head phantom, we illustrate that LTSE PR allows for a significantly shorter longitudinal dimension of MLICs. We compared PR simulations for two exemplary 30 × 30 mm2proton fields passing the phantom at a 90° angle at an anterior and a posterior location in an iso-centric setup. The longitudinal distance over which all spots per field range out is significantly reduced for LTSE PR compared to mono-energetic PR. In addition, we illustrate the difference in shape of integral depth dose (IDD) when using constrained PR energies. Finally, we demonstrate the accordance of simulated and experimentally acquired IDDs for an LTSE PR acquisition. As the next steps, the framework will be used to investigate the sensitivity of LTSE PR to various sources of errors. Furthermore, we will use the framework to systematically explore the dimensions of an optimized MLIC design for daily clinical use.
01A - Beitrag in wissenschaftlicher Zeitschrift
Effects of false alarms and miscues of decision support systems on human–machine system performance: a study with airport security screeners
(Taylor & Francis, 2025) Hügli, David; Chavaillaz, Alain; Sauer, Jürgen; Schwaninger, Adrian
01A - Beitrag in wissenschaftlicher Zeitschrift