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Molecular insights into the formation of drug-​monoacyl phosphatidylcholine solid dispersions for oral delivery 

Gautschi, Nicolas; van Hoogevest, P.; Kuentz, Martin (2016)
Phospholipid-​based formulations provide a key technol. to formulate poorly water-​sol. drugs. A recent interest has been in using phospholipids with a high content of monoacyl phosphatidylcholine (monoacyl PC) due to its ...
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Rapid determination of drug solubilization versus supersaturation in natural and digested lipids 

Gautschi, Nicolas; Bergstroem, Christel; Kuentz, Martin (2016)
Lipid-​based formulations (LBFs) represent one of the successful formulation approaches that enable oral delivery of poorly water-​sol. drugs. This work presents a simple equil. approach based on soly. in lipids and their ...
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Novel Polyurethane Matrix Systems Reveal a Particular Sustained Release Behavior Studied by Imaging and Computational Modeling 

Campinez, Maria Dolores; Caraballo, Isidoro; Puchkow, Maxim; Kuentz, Martin (2016)
The aim of the present work was to better understand the drug-​release mechanism from sustained release matrixes prepd. with two new polyurethanes, using a novel in silico formulation tool based on 3-​dimensional cellular ...
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A new polymer/lipid system for hot-melt extrusion by designing a microstructure on an inorganic carrier 

Adler, Camille; Teleki, A.; Kuentz, Martin; Schönenberger, M. (2016)
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Multifractal Analysis and Dispersion Imaging of Pharmaceutical Hot -Melt E xtrudates 

Adler, Camille; Teleki, A.; Kuentz, Martin (2016)
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Molecularly designed lipid microdomains for solid dispersions using a polymer/inorganic carrier matrix produced by hot-melt extrusion 

Adler, Camille; Schönenberger, Monica; Teleki, A.; Kuentz, Martin (2016-02-29)
Amorphous solid dispersions have for many years been a focus in oral formulations, especially in combination with a hot-melt extrusion process. The present work targets a novel approach with a system based on a fatty acid, ...
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Trends in the Assessment of Drug Supersaturation and Precipitation In Vitro Using Lipid-Based Delivery Systems 

Stillhart, Cordula; Kuentz, Martin (2016)
The generation of drug supersaturation close to the absorptive site is an important mechanism of how several formulation technologies enhance oral absorption and bioavailability. Lipid-based formulations belong to the ...
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Multifractal Characterization of Pharmaceutical Hot-Melt Extrudates 

Adler, Camille; Teleki, A.; Kuentz, Martin (2016)
PURPOSE: Multifractal geometry has become a powerful tool to describe complex structures in many fields. Our first aim was to combine imaging and multifractal analysis to better understand the microstructure of pharmaceutical ...
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On prilled Nanotubes-in-Microgel Oral Systems for protein delivery 

De Kruif, Jan; Kuentz, Martin; Ledergerber, Gisela; Garofalo, Carla; Fasler-Kan, Elizaveta (2016)
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Pharmaceutical excipients — quality, regulatory and biopharmaceutical considerations 

Elder, David; Kuentz, Martin; Holm, Rene (2016)
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Autorin/Autor
Kuentz, Martin (20)
Adler, Camille (5)Teleki, A. (5)Kirchmeyer, Wiebke (4)Alsenz, Jochem (3)Elder, David (3)Holm, Rene (3)Bravo, R. (2)De Kruif, Jan (2)Gautschi, Nicolas (2)... mehrThemaabsorption (1)Acidic lipid (1)amorphous drug (1)Analytical tools; Crystalline active compound; Flow-through cross-polarized imaging; Sampling issues; Sensitivity limits; Solid lipid formulations (1)bioavailability (1)Biological digestion (1)capsule compatibility; encapsulation; excipient compatibility; hydrogels; lipids; microgels; partial least squares; phase diagram; prilling; protein delivery (1)Colloids (1)Continuous water channels (1)crystallization tendency (1)... mehrErscheinungsdatum2016 (16)2015 (4)Has File(s)No (20)

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