Anzeige der Eintraege 1-10 von 20
Molecular insights into the formation of drug-monoacyl phosphatidylcholine solid dispersions for oral delivery
Phospholipid-based formulations provide a key technol. to formulate poorly water-sol. drugs. A recent interest has been in using phospholipids with a high content of monoacyl phosphatidylcholine (monoacyl PC) due to its ...
Rapid determination of drug solubilization versus supersaturation in natural and digested lipids
Lipid-based formulations (LBFs) represent one of the successful formulation approaches that enable oral delivery of poorly water-sol. drugs. This work presents a simple equil. approach based on soly. in lipids and their ...
Novel Polyurethane Matrix Systems Reveal a Particular Sustained Release Behavior Studied by Imaging and Computational Modeling
The aim of the present work was to better understand the drug-release mechanism from sustained release matrixes prepd. with two new polyurethanes, using a novel in silico formulation tool based on 3-dimensional cellular ...
Molecularly designed lipid microdomains for solid dispersions using a polymer/inorganic carrier matrix produced by hot-melt extrusion
Amorphous solid dispersions have for many years been a focus in oral formulations, especially in combination with a hot-melt extrusion process. The present work targets a novel approach with a system based on a fatty acid, ...
Trends in the Assessment of Drug Supersaturation and Precipitation In Vitro Using Lipid-Based Delivery Systems
The generation of drug supersaturation close to the absorptive site is an important mechanism of how several formulation technologies enhance oral absorption and bioavailability. Lipid-based formulations belong to the ...
Multifractal Characterization of Pharmaceutical Hot-Melt Extrudates
PURPOSE: Multifractal geometry has become a powerful tool to describe complex structures in many fields. Our first aim was to combine imaging and multifractal analysis to better understand the microstructure of pharmaceutical ...