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A Systematic Study on Manufacturing of Prilled Microgels into Lipids for Oral Protein Delivery.
(Wiley, 2015-10)
The development of novel systems with oral protein delivery as ultimate goal represents an important field of pharmaceutics. Prilling of protein-loaded polymeric solutions into lipid-based hardening baths could provide ...
Flow-through cross-polarized imaging as a new tool to overcome the analytical sensitivity challenges of a low-dose crystalline compound in a lipid matrix
(Elsevier, 2015-11-10)
Assessing the physical state of a low-dose active compound in a solid lipid or polymer matrix is analytically challenging, especially if the matrix exhibits some crystallinity. The aim of this study was first to compare ...
Using Physiologically Based Pharmacokinetic (PBPK) Modelling to Gain Insights into the Effect of Physiological Factors on Oral Absorption in Paediatric Populations
(2016-07-08)
Paediatric pharmaceutics has become an important topic, but currently, there is an incomplete knowledge of paediatric gastrointestinal physiology and adequate biopharmaceutical tools still have to be developed. The present ...
Methodology of oral formulation selection in the pharmaceutical industry
(2016-05-25)
Pharmaceutical formulations have to fulfil various requirements with respect to their intended use, either in the development phase or as a commercial product. New drug candidates with their specific properties confront ...
Antibiotic Resistance: The Need For a Global Strategy
(2016)
The development of antibiotic resistance is a major problem for mankind and results in fatal consequences on a daily basis across the globe. There are a no. of reasons for this situation including increasing globalization ...
Rapid determination of drug solubilization versus supersaturation in natural and digested lipids
(2016)
Lipid-based formulations (LBFs) represent one of the successful formulation approaches that enable oral delivery of poorly water-sol. drugs. This work presents a simple equil. approach based on soly. in lipids and their ...
Theoretical Considerations of the Prigogine–Defay Ratio with Regard to the Glass-Forming Ability of Drugs from Undercooled Melts
(2016)
Drug behavior in undercooled melts is highly important for pharmaceutics with regard to amorphous solid dispersions, and therefore, categories were recently introduced that differentiate glass formers (GFs) from other drugs ...