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Polyelectrolytes in Hot Melt Extrusion: A Combined Solvent-Based and Interacting Additive Technique for Solid Dispersions
(2019)
Pharmaceutics
Solid dispersions are important supersaturating formulations to orally deliver poorly water-soluble drugs. A most important process technique is hot melt extrusion but process requirements limit the choice of suitable ...
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Novel Biphasic Lipolysis Method To Predict in Vivo Performance of Lipid-Based Formulations
(2020-08-21)
Molecular Pharmaceutics
The absence of an intestinal absorption sink is a significant weakness of standard in vitro lipolysis methods, potentially leading to poor prediction of in vivo performance and an overestimation of drug precipitation. In ...
01 - Zeitschriftenartikel, Journalartikel oder Magazin
Solubility of mesalazine in {1-propanol/water} mixtures at different temperatures
(2020-03-01)
Journal of Molecular Liquids
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Solubility of 5-aminosalicylic acid in N-methyl-2-pyrrolidone + water mixtures at various temperatures
(2020-04-19)
Journal of Molecular Liquids
Drug solubility studies in solvent mixtures have great importance in the pharmaceutical sciences especially in pharmaceutical technology. Advancements in thermodynamic modeling enable a better mechanistic understanding and ...
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Partial Solvation Parameters of Drugs as a New Thermodynamic Tool for Pharmaceutics
(2019-01-04)
Pharmaceutics
Partial solvation parameters (PSP) have much in common with the Hansen solubility parameter or with a linear solvation energy relationship (LSER), but there are advantages based on the sound thermodynamic basis. It is, ...
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Supersaturated Lipid-Based Formulations to Enhance the Oral Bioavailability of Venetoclax
(2020-06-18)
Pharmaceutics
Increasing numbers of beyond Rule-of-Five drugs are emerging from discovery pipelines, generating a need for bio-enabling formulation approaches, such as lipid-based formulations (LBF), to ensure maximal in vivo exposure. ...
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Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems
(2019-09-01)
European Journal of Pharmaceutical Sciences
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Predicting the Angle of Internal Friction from Simple Dynamic Consolidation Using Lactose Grades as Model
(2019-03-28)
Journal of Pharmaceutical Innovation
Powder flow and packing behavior are among other factors determined by particle friction, which is traditionally measured in shear cells as the angle of internal friction (AIF). Considering that an AIF at a normal stress ...
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Mechanistic aspects of drug loading in liquisolid systems with hydrophilic lipid-based mixtures
(2020-01-30)
International Journal of Pharmaceutics
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Exploring the Impact of Surfactant Type and Digestion: Highly Digestible Surfactants Improve Oral Bioavailability of Nilotinib
(2020-09-08)
Molecular Pharmaceutics
The scientific rationale for selection of the surfactant type during oral formulation development requires an in-depth understanding of the interplay between surfactant characteristics and biopharmaceutical factors. ...
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