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Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states. 

Litou, Chara; Kuentz, Martin (2019-10-01)
INTRODUCTION: When developing bio-enabling formulations, innovative tools are required to understand and predict in vivo performance and may facilitate approval by regulatory authorities. EMEND® is an example of such a ...
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Supersaturated lipid-based drug delivery systems - exploring impact of lipid composition type and drug properties on supersaturability and physical stability. 

Ilie, Alexandra Roxana; Kuentz, Martin (2020-01-24)
Objective: The objective of this study was to systematically investigate the impact of lipid composition on the ability to design supersaturated lipid-based drug delivery systems (sLBDDS) using three model drugs with ...
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Benefits of Fractal Approaches in Solid Dosage Form Development. 

Abreu-Villela, Renata; Kuentz, Martin (2019-09-06)
Pharmaceutical formulations are complex systems consisting of active pharmaceutical ingredient(s) and a number of excipients selected to provide the intended performance of the product. The understanding of materials' ...
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Ultra-sub-stoichiometric “Dynamic” Bioconjugation Reduces Viscosity by Disrupting Immunoglobulin Oligomerization. 

Gong, Yuhui; Niederquell, Andreas; Kuentz, Martin (2019-09-09)
Monoclonal antibodies (mAb) are a major focus of the pharmaceutical industry, and polyclonal immunoglobulin G (IgG) therapy is used to treat a wide variety of health conditions. As some individuals require mAb/IgG therapy ...
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Incorporation of HPMCAS during loading of glibenclamide onto mesoporous silica improves dissolution and inhibits precipitation. 

Price, Daniel J.; Kuentz, Martin (2020-01)
Mesoporous silica has emerged as an enabling formulation for poorly soluble active pharmaceutical ingredients (APIs). Unlike other formulations, mesoporous silica typically does not inhibit precipitation of supersaturated ...
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Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems 

Boyd, Ben J.; Kuentz, Martin (2019-09-01)
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From Quantum Chemistry to Prediction of Drug Solubility in Glycerides. 

Alsenz, Jochem; Kuentz, Martin (2019-11-04)
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Application of the solubility parameter concept to assistwith oral delivery of poorly water-soluble drugs–a PEARRLreview 

Jankovic, Sandra; Ditzinger, Felix; Kuentz, Martin (2018-02-28)
ObjectivesSolubility parameters have been used for decades in various scientificfields including pharmaceutics. It is, however, still a field of active research bothon a conceptual and experimental level. This work addresses ...
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Calculation of drug-polymer mixing enthalpy as a new screening method of precipitation inhibitors for supersaturating pharmaceutical formulations. 

Kuentz, Martin (2019-03-12)
Supersaturating formulations are widely used to improve the oral bioavailability of poorly soluble drugs. However, supersaturated solutions are thermodynamically unstable and such formulations often must include a precipitation ...
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New Insights into Using Lipid Based Suspensions for 'Brick Dust' Molecules: Case Study of Nilotinib. 

Koehl, Niklas; Kuentz, Martin (2019-02-22)
PurposeLipid suspensions have been shown to be a suitablebio-enabling formulation approach for highly lipophilic or‘grease ball’drug molecules, but studies on‘brick dust’drugsare lacking. This study explored the utility ...
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Kuentz, Martin (19)
Ditzinger, Felix (5)Jankovic, Sandra (3)Niederquell, Andreas (3)Price, Daniel J. (2)Abreu-Villela, Renata (1)Alsenz, Jochem (1)Becker-Baldus, Johanna (1)Boyd, Ben J. (1)Dejoie, Catherine (1)... mehrThemahot melt extrusion (4)poorly water-soluble drug (3)Precipitation inhibition (2)solubility (2)Supersaturation (2)amorphous solid dispersion (1)amorphous solid dispersions (1)amorphous stability (1)Angle of internal friction (1)Aprepitant (1)... mehrErscheinungsdatum2019 (14)2020 (4)2018 (1)Has File(s)No (13)Yes (6)

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