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Modified Polymer Matrix in Pharmaceutical Hot Melt Extrusion by Molecular Interactions with a Carboxylic Coformer
(2019)
Molecular Pharmaceutics
Hot melt extrusion (HME) has become an essential technology to cope with an increasing number of poorly soluble drug candidates. However, there is only a limited choice of pharmaceutical polymers for obtaining suitable ...
01 - Zeitschriftenartikel, Journalartikel oder Magazin
Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs – a PEARRL review
(2018-07)
Journal of Pharmacy and Pharmacology
Objectives
Solubility parameters have been used for decades in various scientific fields including pharmaceutics. It is, however, still a field of active research both on a conceptual and experimental level. This work ...
01 - Zeitschriftenartikel, Journalartikel oder Magazin
Lipophilicity and hydrophobicity considerations in bio‐enabling oral formulations approaches – a PEARRL review
(2018-08)
Journal of Pharmacy and Pharmacology
Objectives
This review highlights aspects of drug hydrophobicity and lipophilicity as determinants of different oral formulation approaches with specific focus on enabling formulation technologies. An overview is provided ...
01 - Zeitschriftenartikel, Journalartikel oder Magazin
In Vivo Performance of Innovative Polyelectrolyte Matrices for Hot Melt Extrusion of Amorphous Drug Systems
(2020)
Molecular Pharmaceutics
Hot melt extrusion of amorphous systems has become a pivotal technology to cope with challenges of poorly water-soluble drugs. Previous research showed that small molecular additives with targeted molecular interactions ...
01 - Zeitschriftenartikel, Journalartikel oder Magazin