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Novel perfused compression bioreactor system as an in vitro model to investigate fracture healing
Secondary bone fracture healing is a physiological process that leads to functional tissue regeneration via endochondral bone formation. In vivo studies have demonstrated that early mobilization and the application of ...
Mechanical anisotropy of titanium scaffolds
The clinical performance of an implant, e.g. for the treatment of large bone defects, depends on the implant material, anchorage, surface topography and chemistry, but also on the mechanical properties, like the stiffness. ...
Investigation of structural resorption behavior of biphasic bioceramics with help of gravimetry, μCT, SEM, and XRD
Resorbable bone substitute materials are widely used for bone augmentation after tumor resection, parallel to implant placement, or in critical size bone defects. In this study, the structural dissolution of a biphasic ...
Damping of selective-laser-melted NiTi for medical implants
NiTi exhibits distinct damping properties associated with the martensite-austenite transformation. We fabricated net-shape NiTi parts layer-by-layer using a laser beam that locally melted the NiTi powder. The damping ...
Biotechnologies for Critical Raw Material Recovery from Primary and Secondary Sources: R&D Priorities and Future Perspectives
Europe is confronted with an increasing supply risk of critical raw materials. These can be defined as materials of which the risks of supply shortage and their impacts on the economy are higher compared to most of other ...
A Systematic Study on Manufacturing of Prilled Microgels into Lipids for Oral Protein Delivery.
The development of novel systems with oral protein delivery as ultimate goal represents an important field of pharmaceutics. Prilling of protein-loaded polymeric solutions into lipid-based hardening baths could provide ...
Bone regeneration by the osteoconductivity of porous titanium implants manufactured by selective laser melting: A histological and µCT study in the rabbit
The treatment of large bone defects still poses a major challenge in orthopaedic and cranio-maxillofacial surgery. One possible solution could be the development of personalized porous titanium-based implants that are ...
Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review
(American Chemical Society, 2015)
Validation of UHPLC-MS/MS methods for the determination of kaempferol and its metabolite 4-hydroxyphenyl acetic acid, and application to in vitro blood-brain barrier and intestinal drug permeability studies
Sedative and anxiolytic-like properties of flavonoids such as kaempferol and quercetin, and of some of their intestinal metabolites, have been demonstrated in pharmacological studies. However, routes of administration were ...