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The new LassoLoop360° technique for biomechanically superior tissue grip
PurposeSuprapectoral tenodesis is a frequently used technique for treating pathologies of the long head of the biceps bra-chii (LHBB) tendon. However, so far, no Gold Standard treatment exist. Hence, the arthroscopic ...
Matrix Metalloprotease Triggered Bioresponsive Drug Delivery Systems–Design, Synthesis and Application
Engineering of drug delivery systems has evolved in recent decades from comparably simple designs that merely controlled drug release to complex, often multistage systems that respond to multiple biological or environmental ...
GABAA receptor activity modulating piperine analogs: In vitro metabolic stability, metabolite identification, CYP450 reaction phenotyping, and protein binding
In a screening of natural products for allosteric modulators of GABAA receptors (γ-aminobutyric acid type A receptor), piperine was identified as a compound targeting a benzodiazepine-independent binding site. Given that ...
Theoretical Considerations of the Prigogine–Defay Ratio with Regard to the Glass-Forming Ability of Drugs from Undercooled Melts
Drug behavior in undercooled melts is highly important for pharmaceutics with regard to amorphous solid dispersions, and therefore, categories were recently introduced that differentiate glass formers (GFs) from other drugs ...
Toward simplified oral lipid-based drug delivery using mono-/di-glycerides as single component excipients
Objective: This study aimed to systematically explore compositional effects for a series of lipid systems, on the in vitro drug solubilization and in vivo bioavailability of three poorly water-soluble drugs with different ...
Container Closure Integrity Testing of Prefilled Syringes,
Prefilled syringes (PFSs) are increasingly preferred over vials as container closure systems (CCSs) for injectable drug products when facilitated or self-administration is required. However, PFSs are more complex compared ...