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Implementation of a human renal proximal tubule on a chip for nephrotoxicity and drug interaction studies

Suter-Dick, Laura; Caj, Michaela; Hutter, Simon; Vormann, Marianne; Vriend, Jelle; Lanz, Henriette; Gijzen, Linda; van den Heuvel, Angelique; Joore, Jos; Trietsch, Sebastian; Stuut, Christaan; Nieskens, Tom T.G.; Peters, Janny; Ramp, Daniela; Russel, Frans; Roth, Adrian; Lu, Shuyan; Polli, Joseph; Jacobsen, Björn (Elsevier, 2021-04-04)

Journal of Pharmaceutical Sciences

Proximal tubule epithelial cells (PTEC) are susceptible to drug-induced kidney injury (DIKI). Cell-based, two-dimensional (2D) in vitro PTEC models are often poor predictors of DIKI, probably due to the lack of physiological ...

01 - Zeitschriftenartikel, Journalartikel oder Magazin

Nephroscreen. A robust and versatile renal tubule-on-a-chip platform for nephrotoxicity assessment

Suter-Dick, Laura; Vriend, Jelle; Vormann, Marianne; Lanz, Henriette; Joore, Jos; Trietsch, Sebastian J.; Russel, Frans; Jacobsen, Björn; Roth, Adrian; Lu, Shuyan; Polli, Joseph; Naidoo, Anita; Masereeuw, Rosalinde; Wilmer, Martijn (Elsevier, 2021-03)

Current Opinion in Toxicology

Proximal tubule epithelial cells are the main driver of renal transport and secretion of xenobiotics, making them susceptible to drug-induced kidney injury. Cell-based assays are a meaningful alternative to animal testing ...