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Partial Solvation Parameters of Drugs as a New Thermodynamic Tool for Pharmaceutics
(2019-01-04)
Pharmaceutics
Partial solvation parameters (PSP) have much in common with the Hansen solubility parameter or with a linear solvation energy relationship (LSER), but there are advantages based on the sound thermodynamic basis. It is, ...
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Mechanistic aspects of drug loading in liquisolid systems with hydrophilic lipid-based mixtures
(2020-01-30)
International Journal of Pharmaceutics
01 - Zeitschriftenartikel, Journalartikel oder Magazin
A diffusing wave spectroscopy study of pharmaceutical emulsions for physical stability assessment
(2017)
International Journal of Pharmaceutics
Emulsions are broadly used in pharmaceutics either as intermediate products or as final dosage forms. Such disperse systems are only kinetically stabilized and therefore early detection of physical instability is highly ...
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Biorelevant drug solubility enhancement modeled by a linear solvation energy relationship
(2017)
Journal of Pharmaceutical Sciences
It is for the pharmaceutical sciences of vital importance to understand how drugs are solubilized in biorelevant media. However, the complexity of fasted state simulated intestinal fluid (FaSSIF) has so far hampered adequate ...
01 - Zeitschriftenartikel, Journalartikel oder Magazin
Machine Estimation of Drug Melting Properties and Influence on Solubility Prediction
(2020-06-04)
Molecular Pharmaceutics
There has been much recent interest in machine learning (ML) and molecular quantitative structure property relationships (QSPR). The present research evaluated modern ML-based methods implemented in commercial software ...
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A Relative Permittivity Approach for Fast Drug Solubility Screening of Solvents and Excipients in Lipid-Based Delivery
(2019)
Journal of Pharmaceutical Sciences
Drug solubility screening in solvents and lipids is central for the development of lipid-based formulations (LBFs), and any guidance to reduce the experimental workload would be highly desirable. Solubility parameters are ...
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Ultra-sub-stoichiometric “Dynamic” Bioconjugation Reduces Viscosity by Disrupting Immunoglobulin Oligomerization
(2019-09-09)
Biomacromolecules
Monoclonal antibodies (mAb) are a major focus of the pharmaceutical industry, and polyclonal immunoglobulin G (IgG) therapy is used to treat a wide variety of health conditions. As some individuals require mAb/IgG therapy ...
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Temperature-Induced Surface Effects on Drug Nanosuspensions
(2018-02)
Pharmaceutical Research
Purpose
The trial-and-error approach is still predominantly used in pharmaceutical development of nanosuspensions. Physicochemical dispersion stability is a primary focus and therefore, various analytical bulk methods are ...
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Study and computational modeling of fatty acid effects on drug solubility in lipid-based systems
(Elsevier, 2022-06)
Journal of Pharmaceutical Sciences
Lipid-based systems have many advantages in formulation of poorly water-soluble drugs but issues of a limited solvent capacity are often encountered in development. One of the possible solubilization approaches of especially ...
01A - Beitrag in wissenschaftlicher Zeitschrift
New prediction methods for solubility parameters based on molecular sigma profiles using pharmaceutical materials
(2018-07)
International Journal of Pharmaceuticals
Solubility parameters have been applied extensively in the chemical and pharmaceutical sciences. Particularly attractive is calculation of solubility parameters based on chemical structure and recently, new in silico methods ...
01 - Zeitschriftenartikel, Journalartikel oder Magazin