Novel polyurethane matrix systems reveal a particular release mechanism for sustained drug delivery by imaging and computational modeling
Loading...
Authors
Author (Corporation)
Publication date
2017
Typ of student thesis
Course of study
Collections
Type
01A - Journal article
Editors
Editor (Corporation)
Supervisor
Parent work
AAPS PharmSciTech
Special issue
DOI of the original publication
Link
Series
Series number
Volume
18
Issue / Number
5
Pages / Duration
1544-1553
Patent number
Publisher / Publishing institution
Springer
Place of publication / Event location
Edition
Version
Programming language
Assignee
Practice partner / Client
Abstract
The aim of the present work was to better understand the drug-release mechanism from sustained release matrices prepared with two new polyurethanes, using a novel in silico formulation tool based on 3-dimensional cellular automata. For this purpose, two polymers and theophylline as model drug were used to prepare binary matrix tablets. Each formulation was simulated in silico, and its release behavior was compared to the experimental drug release profiles. Furthermore, the polymer distributions in the tablets were imaged by scanning electron microscopy (SEM) and the changes produced by the tortuosity were quantified and verified using experimental data. The obtained results showed that the polymers exhibited a surprisingly high ability for controlling drug release at low excipient concentrations (only 10% w/w of excipient controlled the release of drug during almost 8 h). The mesoscopic in silico model helped to reveal how the novel biopolymers were controlling drug release. The mechanism was found to be a special geometrical arrangement of the excipient particles, creating an almost continuous barrier surrounding the drug in a very effective way, comparable to lipid or waxy excipients but with the advantages of a much higher compactability, stability, and absence of excipient polymorphism.
Keywords
controlled release, drug delivery systems, imaging methods, in silico modeling polyurethanes
Subject (DDC)
Event
Exhibition start date
Exhibition end date
Conference start date
Conference end date
Date of the last check
ISBN
ISSN
1530-9932
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
License
Citation
Campinez, M. D., Caraballo, I., Puchkov, M., & Kuentz, M. (2017). Novel polyurethane matrix systems reveal a particular release mechanism for sustained drug delivery by imaging and computational modeling. AAPS PharmSciTech, 18(5), 1544–1553. https://doi.org/10.1208/s12249-016-0613-0