Peripheral epithelial corneal hyperfluorescence (PECH) in daily soft contact lens (CL) wear is described by three case reports. In vivo confocal microscopy (IVCM) measurements show the presence of epithelial corneal hypertrophy on affected eyes. A statistical analysis of a group of patients with PECH in comparison to a control group suggests a hypoxic cause for PECH. Further clinical studies with balanced patient populations are required to confirm these findings, as the population of this study group was affected by a selection bias.