de Wild, Michael

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Michael
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de Wild, Michael

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2002 - 200912010 - 20143
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Enddatum: 2019 × Dateien dazu vorhanden?: Ja ×

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  • Vorschaubild
    Publikation
    Rapid prototyped porous nickel–titanium scaffolds as bone substitutes
    (SAGE, 17.01.2014) Hoffmann, Waldemar; Bormann, Therese; Rossi, Antonella; Müller, Bert; Schumacher, Ralf; Martin, Ivan; de Wild, Michael; Wendt, David [in: Journal of Tissue Engineering]
    While calcium phosphate–based ceramics are currently the most widely used materials in bone repair, they generally lack tensile strength for initial load bearing. Bulk titanium is the gold standard of metallic implant materials, but does not match the mechanical properties of the surrounding bone, potentially leading to problems of fixation and bone resorption. As an alternative, nickel–titanium alloys possess a unique combination of mechanical properties including a relatively low elastic modulus, pseudoelasticity, and high damping capacity, matching the properties of bone better than any other metallic material. With the ultimate goal of fabricating porous implants for spinal, orthopedic and dental applications, nickel–titanium substrates were fabricated by means of selective laser melting. The response of human mesenchymal stromal cells to the nickel–titanium substrates was compared to mesenchymal stromal cells cultured on clinically used titanium. Selective laser melted titanium as well as surface-treated nickel–titanium and titanium served as controls. Mesenchymal stromal cells had similar proliferation rates when cultured on selective laser melted nickel–titanium, clinically used titanium, or controls. Osteogenic differentiation was similar for mesenchymal stromal cells cultured on the selected materials, as indicated by similar gene expression levels of bone sialoprotein and osteocalcin. Mesenchymal stromal cells seeded and cultured on porous three-dimensional selective laser melted nickel–titanium scaffolds homogeneously colonized the scaffold, and following osteogenic induction, filled the scaffold’s pore volume with extracellular matrix. The combination of bone-related mechanical properties of selective laser melted nickel–titanium with its cytocompatibility and support of osteogenic differentiation of mesenchymal stromal cells highlights its potential as a superior bone substitute as compared to clinically used titanium.
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Vorschaubild
    Publikation
    Comparison of methods for testing ultrasound in the cleaning bath
    (2014) Zwahlen, Alexander; de Wild, Michael; Jung, Christiane [in: Fortschritte der Akustik - DAGA 2014]
    04B - Beitrag Konferenzschrift
  • Vorschaubild
    Publikation
    Reinigungseffektivität und Kavitationsrauschpegel bei Ultraschall-unterstützter wässriger Reinigung von Medizinprodukten
    (2012) Jung, Christiane; Budesa, Boris; Fässler, Fabian; Uehlinger, Robert; Müller, Thomas; Schaffner, Patrik; Bläsi, Simon; de Wild, Michael [in: Tagungsband der 38. Deutschen Jahrestagung für Akustik DAGA 2012 in Darmstadt]
    04B - Beitrag Konferenzschrift
  • Vorschaubild
    Publikation
    Molecular assembly and self-assembly. Molecular nanoscience for future technologies
    (Schweizerische Chemische Gesellschaft, 2002) de Wild, Michael; Berner, Simon; Suzuki, Hitoshi; Ramoino, Luca; Baratoff, Alexis; Jung, Thomas A. [in: Chimia]
    In this review the emerging science of single molecules is discussed from the perspective of nanoscale molecular functions and devices. New methods for the controlled assembly of well-defined mo lecular nanostructures are presented: self assembly and single molecular positioning. The observation and selective modification of conformation, electronics, and molecular mechanics of individual molecules and molecular assemblies by scanning probes are demonstrated. To complement this scientific review, some of the possible consequences and visions for future developments are discussed, as far as they derive from the presented systems. Here, the prospects of nanoscale science to stimulate technological evolution are ex emplified.
    01A - Beitrag in wissenschaftlicher Zeitschrift