Gössi, Angelo
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In-situ recovery of carboxylic acids from fermentation broths through membrane supported reactive extraction using membrane modules with improved stability
2020-06-15, Gössi, Angelo, Burgener, Florian, Kohler, David, Urso, Alessandro, Kolvenbach, Boris, Riedl, Wolfgang
Membrane supported reactive extraction (MSE) coupled to back-extraction (MSBE) using a new type of Teflon (PTFE) capillary membrane contactor was studied for the in-situ removal of carboxylic acids from aqueous streams, e.g. fermentation broths. The use of microporous membranes as extraction interface helps avoiding emulsification problems, allows the use of extreme phase ratios, and protects microorganisms, as they are less affected by solvent toxicity during in-situ extractions. The use of PTFE capillary membranes is suitable for long-term use due its high chemical and thermal stability. A simple toxicity screening identified n-decanol with tri n-octyl amine (TOA) as a suitable solvent. MSE experiments were performed using membrane contactors (0.005 m2 to 0.15 m2), working with solvent to feed phase ratios down to 1:40 (mass based). The in-situ removal of lactic acid out of fermentation broths using lactobacillus plantarum led to a glucose conversion rate of 80 mol%. Additionally, a concentration factor up to 7.8 could be shown during back-extraction.
Continuous Processes and Flow Chemistry at the Universities of Applied Sciences in Switzerland
2017-08, Allemann, Christophe, Marti, Roger, Vorlet, Olivier, Martin, Olivier, Riedelberger, Peter, Leonhardt, Tobias, Gössi, Angelo, Riedl, Wolfgang, Segura, Jean-Manuel, Zinn, Manfred, Crelier, Simon
This article provides an overview of activities in the fields of continuous processes, flow chemistry and microreactors at the Universities of Applied Sciences in Switzerland.
Extraction and back-extraction of lactic acid from aqueous feeds using membrane supported reactive extraction
2016-11, Riedl, Wolfgang, Gössi, Angelo, Schär, Pascal, Schuur, Boelo
Industrial Upscaling of DOPO-Based Phosphonamidates and Phosphonates Derivatives Using Cl2 Gas as a Chlorinating Agent
2018-10, Salmeia, Khalifah A., Baumgartner, Georg, Jovic, Milijana, Gössi, Angelo, Riedl, Wolfgang, Zich, Thomas, Gaan, Sabyasachi
Herein, we report the industrial synthesis procedure of phosphonamidate and phosphonate derivatives via an efficient and simple chlorination of 9,10-dihydro-9-oxa-10-phosphaphenanthren-10-oxide (DOPO) with Cl2 gas. The key step in the synthesis is the conversion of the P–H bond to P–Cl of DOPO by flowing Cl2 gas into a solution of DOPO in dichloromethane, affording the key intermediate 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-chloride (DOPO-Cl) compound which is industrially not available. DOPO-Cl was isolated, characterized, and used for this synthesis of DOPO-based phosphonamidates and phosphonates in relatively high yield by reaction with the corresponding amines and alcohols, respectively. The experimental results show that the chlorination reaction occurs in equimolar ratios of Cl2 gas to DOPO compound. Subsequently, the procedure developed in laboratory scale was industrially applied for synthesis of the 6,6′-(ethane-1,2-diylbis(azanediyl))bis(dibenzo[c,e][1,2]oxaphosphinine-6-oxide) (EDA-DOPO) compound and 6-((1-oxido-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octan-4-yl)methoxy)dibenzo[c,e][1,2]oxaphosphinine-6-oxide (DOPO-PEPA). All synthetic compounds thus obtainedwere characterized and found to be identical to the authentic laboratory scale products.
Extraction of lactic acid from fermentation broths using membrane supported reactive extraction
2017, Gössi, Angelo, Urso, Alessandro, Riedl, Wolfgang, Schuur, Boelo
Extraction of lactic acid from aqueous feeds using membrane supported reactive extraction
2016-09, Gössi, Angelo, Riedl, Wolfgang, Schuur, Boelo
Direktextraktion von Milchsäure aus Fermentationsbrühen mittels membrangestützter flüssig-flüssig Extraktion
2018-09, Kohler, David, Gössi, Angelo, Riedl, Wolfgang, Venus, Joachim, Schuur, Boelo
Enantioseparation with liquid membranes
2017, Gössi, Angelo, Riedl, Wolfgang, Schuur, Boelo
Chiral resolution of racemic products is a challenging and important task in the pharmaceutical, agrochemical, flavor, polymer and fragrances industries. One of the options for these challenging separations is to use liquid membranes. Although liquid membranes have been known for almost four decades and have been used for optical resolutions, no comprehensive review has been published about the use of this technology for enantioseparations. In this review, the various liquid membrane-related technologies are described and compared, including bulk liquid membranes, emulsion liquid membranes, micelle-extraction and micellar enhanced ultrafiltration, as well as supported liquid membranes. Next to technological advances, an overview of recent developments in chiral recognition chemistry in liquid–liquid equilibria is presented. The following extractant classes have recently been reported in conjunction with chiral separation: cyclodextrines, BINOL's, calixarenes, crown ethers, BINAP's, tartaric acids and ionic liquids. The use of two supported (non-liquid) membranes with an inner loop of extract phase appears to be the most stable liquid membrane configuration, allowing for a large degree of freedom in operational conditions such as solvent to feed ratio. The library of solvents still needs broadening to make the technology more versatile and based on the variety of successes with catalytically active organometallic complexes, development of new chiral selector systems based on asymmetric catalysis literature is suggested for future selector screening studies. © 2017 Society of Chemical Industry