Wildhaber, Reto
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Algorithm for real-time analysis of intracoronary electrocardiogram
Since its first implementation in 1985, intracoronary (ic) electrocardiogram (ECG) has shown ample evidence for its diagnostic value given the higher sensitivity for myocardial ischemia detection in comparison to surface ECG. However, a lack of online systems to quantitatively analyze icECG in real-time prevents its routine use. The present study aimed to develop and validate an autonomous icECG analyzing algorithm.
Technical characterization of single-lead ECG signals from 4 different smartwatches and its potential clinical implications
Onset detection of pulse-shaped bioelectrical signals using linear state space models
Bioelectrical signals are often pulse-shaped with superimposed interference signals. In this context, accurate identification of features such as pulse onsets, peaks, amplitudes, and duration is a frequent problem. In this paper, we present a versatile method of rather low computational complexity to robustly identify such features in real-world signals. For that, we take use of two straight-line models fit to the observations by minimizing a quadratic cost term, and then identify desired features by tweaked likelihood measures. To demonstrate the idea and facilitate access to the method, we provide examples from the field of cardiology.
Intracoronary ECG ST-segment shift remission time during reactive coronary hyperemia (tau-icECG): a new approach to assess hemodynamic coronary stenosis severity
Coronary pressure-derived fractional flow reserve (FFR) measurements are recommended for hemodynamic coronary stenosis assessment. Given temporary paralysis of the coronary microcirculation during hyperemia, pressure is, in theory, directly related to coronary flow. Pressure drop during hyperemia across a coronary stenosis, thus, provides an estimate of its restrictive effect on flow. FFR during reactive hyperemia induced by a proximal, 1-minute coronary artery balloon occlusion has been shown non-inferior to FFR as obtained by adenosine-induced hyperemia. Intracoronary ECG (icECG) is more sensitive in detecting myocardial ischemia than the surface ECG, and can be easily obtained.