Wagner, Ulrich
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Wagner
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Ulrich
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Ulrich Wagner
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- PublikationRisk of adverse clinical outcomes in hyponatremic adult patients hospitalized for acute medical conditions. A population-based cohort study(Oxford University Press, 2020) Kutz, Alexander; Ebrahimi, Fahim; Aghlmandi, Soheila; Wagner, Ulrich; Bromley, Miluska; Illigens, Ben; Siepmann, Timo; Schuetz, Philipp; Mueller, Beat; Christ-Crain, Mirjam [in: Journal of Clinical Endocrinology and Metabolism]Hyponatremia has been associated with excess long-term morbidity and mortality. However, effects during hospitalization are poorly studied. Objective The objective of this work is to examine the association of hyponatremia with the risk of in-hospital mortality, 30-day readmission, and other short-term adverse events among medical inpatients. Design and Setting A population-based cohort study was conducted using a Swiss claims database of medical inpatients from January 2012 to December 2017 Patients Hyponatremic patients were 1:1 propensity-score matched with normonatremic medical inpatients. Main Outcome Measure The primary outcome was a composite of all-cause in-hospital mortality and 30-day hospital readmission. Secondary outcomes were intensive care unit (ICU) admission, intubation rate, length-of-hospital stay (LOS), and patient disposition after discharge. Results After matching, 94 352 patients were included in the cohort. Among 47 176 patients with hyponatremia, 8383 (17.8%) reached the primary outcome compared with 7994 (17.0%) in the matched control group (odds ratio [OR] 1.06 [95% CI, 1.02-1.10], P = .001). Hyponatremic patients were more likely to be admitted to the ICU (OR 1.43 [95% CI, 1.37-1.50], P < .001), faced a 56% increase in prolonged LOS (95% CI, 1.52-1.60, P < .001), and were admitted more often to a postacute care facility (OR 1.38 [95% CI 1.34-1.42, P < .001). Of note, patients with the syndrome of inappropriate antidiuresis (SIAD) had lower in-hospital mortality (OR 0.67 [95% CI, 0.56-0.80], P < .001) as compared with matched normonatremic controls. Conclusion In this study, hyponatremia was associated with increased risk of short-term adverse events, primarily driven by higher readmission rates, which was consistent among all outcomes except for decreased in-hospital mortality in SIAD patients.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationSeasonality of hypoosmolar hyponatremia in medical inpatients - data from a nationwide cohort study(Oxford University Press, 2020) Kutz, Alexander; Ebrahimi, Fahim; Sailer, Clara O.; Wagner, Ulrich; Schuetz, Philipp; Mueller, Beat; Christ-Crain, Mirjam [in: Journal of Clinical Endocrinology and Metabolism]https://doi.org/10.1210/clinem/dgz32001A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationExcess mortality among hospitalized patients with hypopituitarism - A population-based, matched-cohort study(Oxford University Press, 2020) Ebrahimi, Fahim; Kutz, Alexander; Wagner, Ulrich; Illigens, Ben; Siepmann, Timo; Schuetz, Philipp; Christ-Crain, Mirjam; Mueller, Beat; Christ, Emanuel R. [in: Journal of Clinical Endocrinology and Metabolism]01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationAssociation of comorbidities with clinical outcomes in patients after acute myocardial infarction(Elsevier, 2020) Baechli, Ciril; Koch, Daniel; Bernet, Selina; Gut, Lara; Wagner, Ulrich; Mueller, Beat; Schuetz, Philipp; Kutz, Alexander [in: International Journal of Cardiology Heart & Vasculature]01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationAssociation of weekend admission and clinical outcomes in hospitalized patients with sepsis(Wolters & Kluwer, 2020) Bernet, Selina; Gut, Lara; Baechli, Ciril; Koch, Daniel; Wagner, Ulrich; Mueller, Beat; Schuetz, Philipp; Kutz, Alexander [in: Medicine]01B - Beitrag in Magazin oder Zeitung
- PublikationAssociation of the Swiss diagnosis-related group reimbursement system with length of stay, mortality, and readmission rates in hospitalized adult patients(American Medical Association, 2019) Kutz, Alexander; Gut, Lara; Ebrahimi, Fahim; Wagner, Ulrich; Schuetz, Philipp; Mueller, Beat [in: JAMA. Journal of the American Medical Association]To examine the association of the SwissDRG implementation with length of hospital stay (LOS), in-hospital mortality, and 30-day readmission rates in the overall adult inpatient population and stratified by 5 individual diagnoses. CONCLUSIONS AND RELEVANCE Among medical hospitalizations in Switzerland, SwissDRG implementation appeared to be associated with an increase in readmission rates and a decrease in in-hospital mortality but not with the gradual decrease in LOS observed in the historical control period.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationAssociation of adrenal insufficiency with patient-oriented health-care outcomes in adult medical inpatients(BioScientifica, 2019) Ebrahimi, Fahim; Widmer, Andrea; Wagner, Ulrich; Mueller, Beat; Schuetz, Philipp; Christ-Crain, Mirjam; Kutz, Alexander [in: European Journal of Endocrinology]01A - Beitrag in wissenschaftlicher Zeitschrift