2023-05, Mancuso, Riccardo V., Schneider, Gisbert, Hürzeler Müller, Marianne, Gut, Martin, Zurflüh, Jonas, Breitenstein, Werner, Bouitbir, Jamal, Reisen, Felix, Atz, Kenneth, Ehrhardt, Claus, Duthaler, Urs, Gygax, Daniel, Schmidt, Albrecht G., Krähenbühl, Stephan, Weitz-Schmidt, Gabriele

2023, Gygax, Daniel, Eigenmann, Kaspar, Suter, Christian, Hürzeler Müller, Marianne, Mahmoud, Ahmed, Mosbacher, Johannes, Pöllinger, Norbert

In this work, we investigated the technical feasibility of 'on-demand' production of selected drugs to cover their demand for a time window of 90 days. We focused on two sub-processes 'automated chemical synthesis' and 'formulation in micropellets'  to enable personalized dosing. The production of drugs 'on-demand' is challenging, important, but also attractive. Switzerland could thus gain access to an additional instrument for increasing resilience for supply-critical drugs. The biggest challenge in the case study presented here is the scalability of automated chemical synthesis and the application range of micropellet formulations.