Jordan, Denis
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Denis Jordan
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- PublikationRelationship of critical dynamics, functional connectivity, and states of consciousness in large-scale human brain networks(Elsevier, 2019) Lee, Heonsoo; Golkowski, Daniel; Jordan, Denis; Berger, Sebastian; Ilg, Rüdiger; Lee, Joseph; Mashour, George A.; Lee, UnCheol; Avidan, Michael S.; Blain-Moraes, Stefanie; Golmirzaie, Goodarz; Hardie, Randall; Hogg, Rosemary; Janke, Ellen; Kelz, Max B.; Maier, Kaitlyn; Mashour, George A.; Maybrier, Hannah; McKinstry-Wu, Andrew; Muench, Maxwell; Ochroch, Andrew; Palanca, Ben J.A.; Picton, Paul; Schwarz, E. Marlon; Tarnal, Vijay; Vanini, Giancarlo; Vlisides, Phillip E. [in: NeuroImage]Recent modeling and empirical studies support the hypothesis that large-scale brain networks function near a critical state. Similar functional connectivity patterns derived from resting state empirical data and brain network models at criticality provide further support. However, despite the strong implication of a relationship, there has been no principled explanation of how criticality shapes the characteristic functional connectivity in large-scale brain networks. Here, we hypothesized that the network science concept of partial phase locking is the underlying mechanism of optimal functional connectivity in the resting state. We further hypothesized that the characteristic connectivity of the critical state provides a theoretical boundary to quantify how far pharmacologically or pathologically perturbed brain connectivity deviates from its critical state, which could enable the differentiation of various states of consciousness with a theory-based metric. To test the hypothesis, we used a neuroanatomically informed brain network model with the resulting source signals projected to electroencephalogram (EEG)-like sensor signals with a forward model. Phase lag entropy (PLE), a measure of phase relation diversity, was estimated and the topography of PLE was analyzed. To measure the distance from criticality, the PLE topography at a critical state was compared with those of the EEG data from baseline consciousness, isoflurane anesthesia, ketamine anesthesia, vegetative state/unresponsive wakefulness syndrome, and minimally conscious state. We demonstrate that the partial phase locking at criticality shapes the functional connectivity and asymmetric anterior-posterior PLE topography, with low (high) PLE for high (low) degree nodes. The topographical similarity and the strength of PLE differentiates various pharmacologic and pathologic states of consciousness. Moreover, this model-based EEG network analysis provides a novel metric to quantify how far a pharmacologically or pathologically perturbed brain network is away from critical state, rather than merely determining whether it is in a critical or non-critical state.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationTeaching ordinal patterns to a computer. Efficient encoding algorithms based on the Lehmer code(MDPI, 2019) Berger, Sebastian; Kravtsiv, Andrii; Schneider, Gerhard; Jordan, Denis [in: Entropy]Ordinal patterns are the common basis of various techniques used in the study of dynamical systems and nonlinear time series analysis. The present article focusses on the computational problem of turning time series into sequences of ordinal patterns. In a first step, a numerical encoding scheme for ordinal patterns is proposed. Utilising the classical Lehmer code, it enumerates ordinal patterns by consecutive non-negative integers, starting from zero. This compact representation considerably simplifies working with ordinal patterns in the digital domain. Subsequently, three algorithms for the efficient extraction of ordinal patterns from time series are discussed, including previously published approaches that can be adapted to the Lehmer code. The respective strengths and weaknesses of those algorithms are discussed, and further substantiated by benchmark results. One of the algorithms stands out in terms of scalability: its run-time increases linearly with both the pattern order and the sequence length, while its memory footprint is practically negligible. These properties enable the study of high-dimensional pattern spaces at low computational cost. In summary, the tools described herein may improve the efficiency of virtually any ordinal pattern-based analysis method, among them quantitative measures like permutation entropy and symbolic transfer entropy, but also techniques like forbidden pattern identification. Moreover, the concepts presented may allow for putting ideas into practice that up to now had been hindered by computational burden. To enable smooth evaluation, a function library written in the C programming language, as well as language bindings and native implementations for various numerical computation environments are provided in the supplements.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationInvestigating roundabout properties and bicycle accident occurrence at Swiss roundabouts: A logistic regression approach(MDPI, 2019) Hollenstein, Daria; Hess, Martin; Jordan, Denis; Bleisch, Susanne [in: ISPRS International Journal of Geo-Information]The positive effects of active mobility on mental and physical health as well as on air quality are widely acknowledged. Increasing the share of active travel is therefore an aim in many countries. Providing bicycle-safe infrastructure is one way to promote cycling. Roundabouts are a common traffic infrastructure and are supposed to facilitate safe and smooth traffic flow. However, data on road traffic accidents indicate an over-proportional involvement of cyclists in accidents at roundabouts. In the present study, the influence of roundabout geometry and traffic flow on bicycle accident occurrence was investigated using a logistic regression approach on twelve parameters of N = 294 mostly small- and mini-sized single-lane roundabouts in the Canton of Berne, Switzerland. Average weekday motorized traffic was identified as a major factor in explaining bicycle accident occurrence at roundabouts. Further, the radius of the central island, the location of the roundabout (in town vs. out of town) and the number of legs were significantly related to bicycle accident occurrence. While these results are in general agreement with findings from similar studies, the findings regarding the central island’s radius and the number of legs underpin the need for roundabout type-specific studies: Some parameters may not prove relevant in intermediate- to large-sized roundabouts, but become critical in small or mini roundabouts, which are common in Switzerland and numerous in the present sample.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationSpectral dynamics of resting state fMRI within the ventral tegmental area and dorsal raphe nuclei in medication-free major depressive disorder in young adults(Frontiers Research Foundation, 2018) Wohlschläger, Afra; Karne, Harish; Jordan, Denis; Lowe, Mark J.; Jones, Stephen E.; Anand, Amit [in: Frontiers in Psychiatry]Background: Dorsal raphe nucleus (DRN) and ventral tegmental area (VTA) are major brainstem monamine nuclei consisting of serotonin and dopamine neurons respectively. Animal studies show that firing patterns in both nuclei are altered when animals exhibit depression like behaviors. Functional MRI studies in humans have shown reduced VTA activation and DRN connectivity in depression. This study for the first time aims at investigating the functional integrity of local neuronal firing concurrently in both the VTA and DRN in vivo in humans using spectral analysis of resting state low frequency fluctuation fMRI. Method: A total of 97 medication-free subjects-67 medication-free young patients (ages 18-30) with major depressive disorder and 30 closely matched healthy controls were included in the study to detect aberrant dynamics in DRN and VTA. For the investigation of altered localized dynamics we conducted power spectral analysis and above this spectral cross correlation between the two groups. Complementary to this, spectral dependence of permutation entropy, an information theoretical measure, was compared between groups. Results: Patients displayed significant spectral slowing in VTA vs. controls (p = 0.035, corrected). In DRN, spectral slowing was less pronounced, but the amount of slowing significantly correlated with 17-item Hamilton Depression Rating scores of depression severity (p = 0.038). Signal complexity as assessed via permutation entropy showed spectral alterations inline with the results on spectral slowing. Conclusion: Our results indicate that altered functional dynamics of VTA and DRN in depression can be detected from regional fMRI signal. On this basis, impact of antidepressant treatment and treatment response can be assessed using these markers in future studies.01A - Beitrag in wissenschaftlicher Zeitschrift