Rausenberger, Julia

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Rausenberger
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Julia
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Rausenberger, Julia

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2016 - 201912020 - 20231
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  • Vorschaubild
    Publikation
    How do students use basic aspects of functional thinking when learning mathematics in a chemistry context?
    (European Society for Engineering Education (SEFI), 2023) Friedhoff, Lars; Roth, Jürgen; Rausenberger, Julia
    The mathematical concept of function is challenging for students in first-year undergraduate mathematics courses, especially when the concept is applied in the context of STEM courses. This difficulty is often due to a lack of conceptual understanding of functions. From a normative perspective, conceptual understanding of functions involves 1) dealing with the different representations of a function, namely table, graph, analytical term and verbal description, while 2) considering three different aspects of functions, namely correspondence, covariation and object. Previous research suggests that the covariation aspect is essential for achieving a sophisticated conceptual understanding of functions. In order to promote the conceptual understanding of functions, a digital self-learning environment was developed and implemented in the first-year basic mathematics course at the School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland (FHNW). To facilitate the transfer of mathematical knowledge to applied STEM courses, the mathematical learning environment focuses on chemical reactions, where the concentration of the reactants is analysed. Initial findings from the qualitative content analysis show 1) how students use the different aspects of mathematical functions in the context of chemical reactions and 2) how the covariation and object aspects support students in linking the chemical context to mathematical representations.
    04B - Beitrag Konferenzschrift
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    Publikation
    In vitro modulation of inflammatory target gene expression by a polyphenol-enriched fraction of rose oil distillation waste water
    (Elsevier, 2016) Weston, Anna; Rausenberger, Julia; Butterweck, Veronika; Wedler, Jonas [in: Fitoterapia]
    Classical production of rose oil is based on water steam distillation from the flowers of Rosa damascena. During this process, large quantities of waste water accrue which are discharged to the environment, causing severe pollution of both, groundwater and surface water due to a high content of polyphenols. We recently developed a strategy to purify the waste water into a polyphenol-depleted and a polyphenol-enriched fraction RF20-(SP-207). RF20-(SP-207) and sub-fraction F(IV) significantly inhibited cell proliferation and migration of HaCaT cells. Since there is a close interplay between these actions and inflammatory processes, here we focused on the fractions' influence on pro-inflammatory biomarkers. HaCaT keratinocytes were treated with RF20-(SP-207), F(IV) (both at 50 μg/mL) and ellagic acid (10 μM) for 24 h under TNF-α (20 ng/mL) stimulated and non-stimulated conditions. Gene expression of IL-1β, IL-6, IL-8, RANTES and MCP-1 was analyzed by reverse transcriptase polymerase chain reaction (RT-PCR) and cellular protein secretion of IL-8, RANTES and MCP-1 was determined by ELISA based assays. RF20-(SP-207) and F(IV) significantly decreased the expression and cellular protein secretion of IL-1β, IL-6, IL-8, RANTES and MCP-1. The diminishing effects on inflammatory target gene expression were slightly less pronounced under TNF-α stimulated conditions. In conclusion, the recovered polyphenol fraction RF20-(SP-207) from rose oil distillation waste water markedly modified inflammatory target gene expression in vitro, and, therefore, could be further developed as alternative treatment of acute and chronic inflammation.
    01A - Beitrag in wissenschaftlicher Zeitschrift