Kidins220 regulates the development of B cells bearing the λ light chain
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Authors
Schaffer, Anna-Maria
Fiala, Gina Jasmin
Hils, Miriam
Natali, Eriberto
Babrak, Lmar
Herr, Laurenz Alexander
Romero-Mulero, Mari Carmen
Cabezas-Wallscheid, Nina
Rizzi, Marta
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Publication date
25.01.2024
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01A - Journal article
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eLife
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eLife Sciences Publications
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Abstract
The ratio between κ and λ light chain (LC)-expressing B cells varies considerably between species. We recently identified Kinase D-interacting substrate of 220 kDa (Kidins220) as an interaction partner of the BCR. In vivo ablation of Kidins220 in B cells resulted in a marked reduction of λLC-expressing B cells. Kidins220 knockout B cells fail to open and recombine the genes of the Igl locus, even in genetic scenarios where the Igk genes cannot be rearranged or where the κLC confers autoreactivity. Igk gene recombination and expression in Kidins220-deficient B cells is normal. Kidins220 regulates the development of λLC B cells by enhancing the survival of developing B cells and thereby extending the time-window in which the Igl locus opens and the genes are rearranged and transcribed. Further, our data suggest that Kidins220 guarantees optimal pre-BCR and BCR signaling to induce Igl locus opening and gene recombination during B cell development and receptor editing.
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600 - Technik, Medizin, angewandte Wissenschaften
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2050-084X
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English
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Yes
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Published
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Gold
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Citation
SCHAFFER, Anna-Maria, Gina Jasmin FIALA, Miriam HILS, Eriberto NATALI, Lmar BABRAK, Laurenz Alexander HERR, Mari Carmen ROMERO-MULERO, Nina CABEZAS-WALLSCHEID, Marta RIZZI, Enkelejda MIHO, Wolfgang W.A. SCHAMEL und Susana MINGUET, 2024. Kidins220 regulates the development of B cells bearing the λ light chain. eLife. 25 Januar 2024. DOI 10.7554/elife.83943. Verfügbar unter: https://doi.org/10.26041/fhnw-9955