An approach towards bronchoscopic-based gene therapy using electrical field accelerated plasmid droplets

dc.contributor.authorHradetzky, David
dc.contributor.authorBoehringer, Stephan
dc.contributor.authorGeiser, Thomas
dc.contributor.authorGazdhar, Amiq
dc.date.accessioned2024-08-13T07:47:10Z
dc.date.available2024-08-13T07:47:10Z
dc.date.issued2012
dc.description.abstractIdiopathic pulmonary fibrosis (IPF) is a devastating disease affecting the distal lung, due to failure of the alveolar epithelium to heal after micro-injuries, leading to inefficient gas exchange and resulting in death. Therapeutic options are very limited. A new therapeutic approach based on gene therapy restores the self-healing process within the lung in the experimental setup. A basic requirement of this therapy is the successful transduction of genes into the alveolar epithelium in the distal part of the lung, for which a new therapeutic instrument is required. In this paper we present the concept and first experimental results of a device which uses an electrical field to accelerate the charged droplets of plasmid suspension toward the tissue and which overcomes cell membrane with its impact energy. The aim is to develop a therapeutic device capable of being integrated into minimally invasive procedures such as bronchoscopy.
dc.event34th Annual International Conference of the IEEE EMBS
dc.event.end2012-09-01
dc.event.start2012-08-28
dc.identifier.doi10.1109/embc.2012.6347301
dc.identifier.urihttps://irf.fhnw.ch/handle/11654/46668
dc.language.isoen
dc.publisherIEEE
dc.relation.ispartof2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society
dc.spatialNew York
dc.subject.ddc600 - Technik, Medizin, angewandte Wissenschaften
dc.titleAn approach towards bronchoscopic-based gene therapy using electrical field accelerated plasmid droplets
dc.type04B - Beitrag Konferenzschrift
dspace.entity.typePublication
fhnw.InventedHereYes
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.affiliation.hochschuleHochschule für Life Sciences FHNWde_CH
fhnw.affiliation.institutInstitut für Medizintechnik und Medizininformatikde_CH
fhnw.openAccessCategoryClosed
fhnw.publicationStatePublished
relation.isAuthorOfPublicationc9dfc5bf-b9cd-4a1b-b606-eee6c639fd56
relation.isAuthorOfPublication.latestForDiscoveryc9dfc5bf-b9cd-4a1b-b606-eee6c639fd56
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