Introduction to predictive toxicology tools and methods
dc.contributor.author | Suter-Dick, Laura | |
dc.contributor.author | Pfannkuch, Friedlieb | |
dc.contributor.editor | Pfannkuch, Friedlieb | |
dc.contributor.editor | Suter-Dick, Laura | |
dc.date.accessioned | 2025-06-20T12:20:10Z | |
dc.date.issued | 2014-11 | |
dc.description.abstract | Computational tools are used in many life sciences research areas, including toxicity prediction. They take advantage of complex mathematical models to predict the effects caused by a given compound on an organism. In silico tools make use of information regarding chemical structures and the immense data legacy that allows inferring interactions between chemical structures, physicochemical properties, and biological processes. The omics technologies arose with the advent of advanced molecular biology techniques able to determine changes in the whole transcriptome, proteome, or metabolome. The integration of highly sensitive molecular biology technologies with the well established pathology assessment also provides a means to identify putative novel biomarkers. In vitro toxicology is not a new concept and the advantages of cell cultures are manifold, including the possibility of screening at low cost and the reduction in animal experimentation, supporting the 3Rs concept (refine, reduce, and replace animal experiments). | |
dc.identifier.isbn | 978-3-527-33608-1 | |
dc.identifier.uri | https://irf.fhnw.ch/handle/11654/51760 | |
dc.language.iso | en | |
dc.publisher | Wiley-VCH | |
dc.relation.ispartof | Predictive Toxocology. From vision to reality | |
dc.relation.ispartofseries | Methods and principles in medicinal chemistry | |
dc.spatial | Weinheim | |
dc.subject.ddc | 600 - Technik, Medizin, angewandte Wissenschaften | |
dc.title | Introduction to predictive toxicology tools and methods | |
dc.type | 04A - Beitrag Sammelband | |
dspace.entity.type | Publication | |
fhnw.InventedHere | Yes | |
fhnw.ReviewType | Lectoring (ex ante) | |
fhnw.affiliation.hochschule | Hochschule für Life Sciences FHNW | de_CH |
fhnw.affiliation.institut | Institut für Chemie und Bioanalytik | de_CH |
fhnw.openAccessCategory | Closed | |
fhnw.pagination | 1-10 | |
fhnw.publicationState | Published | |
fhnw.seriesNumber | 64 | |
fhnw.strategicActionField | Future Health | |
relation.isAuthorOfPublication | 37292405-e311-4093-a2e7-9a72a2511114 | |
relation.isAuthorOfPublication.latestForDiscovery | 37292405-e311-4093-a2e7-9a72a2511114 | |
relation.isEditorOfPublication | 37292405-e311-4093-a2e7-9a72a2511114 | |
relation.isEditorOfPublication.latestForDiscovery | 37292405-e311-4093-a2e7-9a72a2511114 |
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