Virtual supersampling as post-processing step preserves the trabecular bone morphometry in human peripheral quantitative computed tomography scans
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Authors
Schulte, Friederike A.
Badilatti, Sandro D.
Parkinson, Ian
Khosla, Sundeep
Goldhahn, Jörg
Müller, Ralph
Author (Corporation)
Publication date
2019
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Type
01A - Journal article
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PLOS ONE
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Volume
14
Issue / Number
2
Pages / Duration
22-48
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Publisher / Publishing institution
Public Library of Science
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Abstract
In the clinical field of diagnosis and monitoring of bone diseases, high-resolution peripheral quantitative computed tomography (HR-pQCT) is an important imaging modality. It provides a resolution where quantitative bone morphometry can be extracted in vivo on patients. It is known that HR-pQCT provides slight differences in morphometric indices compared to the current standard approach micro-computed tomography (micro-CT). The most obvious reason for this is the restriction of the radiation dose and with this a lower image resolution. With advances in micro-CT evaluation techniques such as patient-specific remodeling simulations or dynamic bone morphometry, a higher image resolution would potentially also allow the application of such novel evaluation techniques to clinical HR-pQCT measurements. Virtual supersampling as post-processing step was considered to increase the image resolution of HR-pQCT scans. The hypothesis was that this technique preserves the structural bone morphometry. Supersampling from 82
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330 - Wirtschaft
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ISSN
1932-6203
Language
English
Created during FHNW affiliation
Yes
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Publication status
Published
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Peer review of the complete publication
Open access category
Gold
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Citation
SCHULTE, Friederike A., Patrik CHRISTEN, Sandro D. BADILATTI, Ian PARKINSON, Sundeep KHOSLA, Jörg GOLDHAHN und Ralph MÜLLER, 2019. Virtual supersampling as post-processing step preserves the trabecular bone morphometry in human peripheral quantitative computed tomography scans. PLOS ONE. 2019. Bd. 14, Nr. 2, S. 22–48. DOI 10.1371/journal.pone.0212280. Verfügbar unter: https://doi.org/10.26041/fhnw-6551