Interferometric label-free biomolecular detection system

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Authors
Mueller, Claas
Reinecke, Holger
Author (Corporation)
Publication date
2006
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Type
01A - Journal article
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Parent work
Journal of Optics A: Pure and Applied Optics
Special issue
DOI of the original publication
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Volume
8
Issue / Number
7
Pages / Duration
360-364
Patent number
Publisher / Publishing institution
IOP Publishing Ltd
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Abstract
This work presents a simple evanescent wave sensing system based on an interferometric approach, suitable to meet the requirements of label-free sensor systems for detecting biomolecular interactions. It represents a basic concept towards label-free detection systems in various applications. The basic objectives of transducers for evanescent wave sensing are discussed. An optical detection system based on a interferometric approach using Young's double slit configuration is discussed, set-up and characterized. With refractometric measurements of various sucrose dilutions, the performance of the pure optical set-up is evaluated.
Keywords
Interferometer, Evanescence wave sensing, Integrated optics, Biosensor
Subject (DDC)
600 - Technik, Medizin, angewandte Wissenschaften
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ISBN
ISSN
1464-4258
1741-3567
Language
English
Created during FHNW affiliation
No
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Publication status
Published
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Peer review of the complete publication
Open access category
Closed
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Citation
HRADETZKY, David, Claas MUELLER und Holger REINECKE, 2006. Interferometric label-free biomolecular detection system. Journal of Optics A: Pure and Applied Optics. 2006. Bd. 8, Nr. 7, S. 360–364. DOI 10.1088/1464-4258/8/7/s11. Verfügbar unter: https://irf.fhnw.ch/handle/11654/46727