Trends in the Assessment of Drug Supersaturation and Precipitation In Vitro Using Lipid-Based Delivery Systems

dc.accessRightsAnonymous
dc.audienceScience
dc.contributor.authorStillhart, Cordula
dc.contributor.authorKuentz, Martin
dc.date.accessioned2016-12-15T16:06:08Z
dc.date.available2016-12-15T16:06:08Z
dc.date.issued2016
dc.description.abstractThe generation of drug supersaturation close to the absorptive site is an important mechanism of how several formulation technologies enhance oral absorption and bioavailability. Lipid-based formulations belong to the supersaturating drug delivery systems although this is not the only mechanism of how drug absorption is promoted in vivo. Different methods to determine drug supersaturation and precipitation from lipid-based formulations are described in the literature. Experimental in vitro setups vary according to their complexity and proximity to the in vivo conditions and, therefore, some tests are used for early formulation screening, while others better qualify for a later stage of development. The present commentary discusses this rapidly evolving field of in vitro testing with a special focus on the advancements in analytical techniques and new approaches of mechanistic modeling. The importance of considering a drug absorption sink is particularly emphasized. This commentary should help formulators in the pharmaceutical industry as well as in academia to make informed decisions on how to conduct in vitro tests for lipid-based delivery systems and to decide on the implications of experimental results.
dc.description.urihttp://www.jpharmsci.org/article/S0022-3549(16)00273-2/fulltext
dc.identifier.doihttp://dx.doi.org/10.1016/j.xphs.2016.01.010
dc.identifier.issn0022-3549
dc.identifier.issn1520-6017
dc.identifier.urihttp://hdl.handle.net/11654/23725
dc.issue9
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Pharmaceutical Sciencesen_US
dc.subjectabsorption
dc.subjectsupersaturation
dc.subjectbioavailability
dc.subjectlipids
dc.subjectmathematical model
dc.titleTrends in the Assessment of Drug Supersaturation and Precipitation In Vitro Using Lipid-Based Delivery Systems
dc.type01A - Beitrag in wissenschaftlicher Zeitschrift
dc.volume105
dspace.entity.typePublication
fhnw.InventedHereYes
fhnw.IsStudentsWorkno
fhnw.PublishedSwitzerlandNo
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.affiliation.hochschuleHochschule für Life Sciencesde_CH
fhnw.affiliation.institutInstitut für Pharma Technologyde_CH
fhnw.pagination2468-2476
fhnw.publicationOnlineJa
fhnw.publicationStatePublished
relation.isAuthorOfPublication68819448-8611-488b-87bc-1b1cf9a6a1b4
relation.isAuthorOfPublication.latestForDiscovery68819448-8611-488b-87bc-1b1cf9a6a1b4
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