Thermoresponsive nanocarriers transduced by inorganic nanoparticles: design considerations and applications in drug delivery
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Author (Corporation)
Publication date
14.03.2025
Typ of student thesis
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Type
01A - Journal article
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Parent work
Helvetica Chimica Acta
Special issue
DOI of the original publication
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Series
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Volume
108
Issue / Number
3
Pages / Duration
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Publisher / Publishing institution
Wiley
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Abstract
Thermoresponsive polymers, which undergo phase transitions within physiologically tolerated temperatures, are key to developing drug delivery systems (DDS) with precise spatial and temporal control, potentially addressing challenges associated with the treatment of complex diseases. Inorganic nanoparticles with unique optical, electronic, and magnetic properties serve as efficient transducers, converting external stimuli into localized heat to trigger thermoresponsive nanocarriers. This review explores the design and application of thermoresponsive nanocarriers transduced by inorganic nanoparticles as DDS. Following a brief description of temperature-triggered phase transition of polymers and heat generation mechanisms by inorganic nanoparticles, strategies to integrate these components into hybrid systems are described. Examples demonstrating the utility of these hybrid systems as advanced DDS are discussed, highlighting their potential for precise drug release alongside theranostic capabilities by combining therapy with imaging. Despite the challenges in design, synthesis, and biological applications, thermoresponsive polymer-inorganic hybrids hold immense promise for transforming drug delivery and biomedical innovations.
Keywords
Drug delivery, Heat transduction, Inorganic nanoparticles, Organic-inorganic hybrid assemblies, Thermoresponsive polymers
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ISBN
ISSN
0018-019X
1522-2675
1522-2675
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Hybrid
License
Citation
Nikoletić, A., Maleković, M., Kozalak, G., Palivan, C. G., & Tagit, O. (2025). Thermoresponsive nanocarriers transduced by inorganic nanoparticles: design considerations and applications in drug delivery. Helvetica Chimica Acta, 108(3). https://doi.org/10.1002/hlca.202400193