Current challenges and future perspectives in oral absorption research. An opinion of the UNGAP network

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Authors
Vinarov, Zahari
Bertil, Abrahamsson
Artursson, Per
Batchelor, Hannah
Berben, Philippe
Bernkop-Schnürch, Andreas
Butler, James
Ceulemans, Jens
Davies, Nigel
Author (Corporation)
Publication date
04/2021
Typ of student thesis
Course of study
Type
01A - Journal article
Editors
Editor (Corporation)
Supervisor
Parent work
Advanced Drug Delivery Reviews
Special issue
DOI of the original publication
Link
Series
Series number
Volume
171
Issue / Number
Pages / Duration
289-331
Patent number
Publisher / Publishing institution
Elsevier
Place of publication / Event location
Edition
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Abstract
Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research.
Keywords
Specific patient populations, Regional differences, Advanced formulations, Amorphous solid dispersions, Lipid-based formulations, Food-drug interactions, Microbiome, In vitro tools, PBPK modeling
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ISBN
ISSN
1872-8294
0169-409X
Language
English
Created during FHNW affiliation
Yes
Publication status
Published
Review
Peer review of the complete publication
Open access category
Hybrid
License
'http://creativecommons.org/licenses/by-nc/3.0/us/'
Citation
KUENTZ, Martin, Zahari VINAROV, Abrahamsson BERTIL, Per ARTURSSON, Hannah BATCHELOR, Philippe BERBEN, Andreas BERNKOP-SCHNÜRCH, James BUTLER, Jens CEULEMANS, Nigel DAVIES, Didier DUPONT, Goril EIDE FLATEN, Nikoleta FOTAKI, Vincent JANNIN, Janneke KEEMINK, Filippos KESISOGLOU, Mirko KOZIOLEK, Patrick AUGUSTIJNS und Brendan GRIFFIN, 2021. Current challenges and future perspectives in oral absorption research. An opinion of the UNGAP network. Advanced Drug Delivery Reviews. April 2021. Bd. 171, S. 289–331. DOI 10.1016/j.addr.2021.02.001. Verfügbar unter: https://doi.org/10.26041/fhnw-4104