A diffusing wave spectroscopy study of pharmaceutical emulsions for physical stability assessment

dc.accessRightsAnonymous
dc.audienceScience
dc.contributor.authorNiederquell, Andreas
dc.contributor.authorMachado, Alexandra H.E.
dc.contributor.authorKuentz, Martin
dc.date.accessioned2018-01-09T12:27:39Z
dc.date.available2018-01-09T12:27:39Z
dc.date.issued2017
dc.description.abstractEmulsions are broadly used in pharmaceutics either as intermediate products or as final dosage forms. Such disperse systems are only kinetically stabilized and therefore early detection of physical instability is highly desirable. This work employed diffusing wave spectroscopy (DWS) to study a series of model emulsions that were categorized, based on their composition, as either “simple” or “complex”. DWS data were compared with results of droplet size imaging, apparent viscosity obtained by microfluidics, and near-infrared (NIR) analytical centrifugation. A mathematical model of the droplet mean square displacement (MSD) was modified by us regarding improved fitting of experimental data. Although the emulsions showed different types of instability like creaming and sedimentation, a good rank correlation was found between the DWS parameters and results from the comparative stability methods. Our findings indicate that DWS provides a highly attractive method for stability analysis of pharmaceutical emulsions because it requires only low sample volumes, is rapid and non-invasive. The proposed data modeling provides the means for a better understanding of emulsion microstructure that in turn will help designing quality into pharmaceutical dispersions.
dc.description.urihttp://www.sciencedirect.com/science/article/pii/S0378517317306373?via%3Dihub
dc.identifier.doi10.1016/j.ijpharm.2017.07.038
dc.identifier.issn0378-5173
dc.identifier.issn1873-3476
dc.identifier.urihttp://hdl.handle.net/11654/25762
dc.issue1-2
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Pharmaceuticsen_US
dc.subjectDiffusing wave spectroscopy
dc.subjectMean square displacement
dc.subjectPharmaceutical emulsions
dc.subjectPhysical stability
dc.subjectXanthan
dc.titleA diffusing wave spectroscopy study of pharmaceutical emulsions for physical stability assessment
dc.type01A - Beitrag in wissenschaftlicher Zeitschrift
dc.volume530
dspace.entity.typePublication
fhnw.InventedHereYes
fhnw.IsStudentsWorkno
fhnw.PublishedSwitzerlandYes
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.affiliation.hochschuleHochschule für Life Sciencesde_CH
fhnw.affiliation.institutInstitut für Pharma Technologyde_CH
fhnw.pagination213-223
fhnw.publicationOnlineJa
fhnw.publicationStatePublished
relation.isAuthorOfPublication06a3358a-d47d-4c9a-8527-ca95e717ed66
relation.isAuthorOfPublication68819448-8611-488b-87bc-1b1cf9a6a1b4
relation.isAuthorOfPublication.latestForDiscovery68819448-8611-488b-87bc-1b1cf9a6a1b4
Dateien