Design and evaluation of mucoadhesive capsule formulations of live biotherapeutic product for vaginal delivery of lactobacillus SPP
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Author (Corporation)
Publication date
2025
Type of student thesis
Course of study
Type
01A - Journal article
Editors
Editor (Corporation)
Supervisor
Parent work
Farmacia
Special issue
DOI of the original publication
Link
Series
Series number
Volume
73
Issue / Number
5
Pages / Duration
1155-1163
Patent number
Publisher / Publishing institution
Societatea de Științe Farmaceutice din România
Place of publication / Event location
Edition
Version
Programming language
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Abstract
Live biotherapeutic products (LBPs) represent a promising therapeutic platform for women's health, primarily by addressing vaginal and reproductive conditions through microbiome modulation. This study explores the design and evaluation of mucoadhesive capsule formulations for targeted, continuous delivery of Lactobacillus spp., directly into the vaginal cavity. By leveraging the anatomical and physiological features of the vagina, together with an understanding of the mucoadhesive and drug-release properties of several polymers, the research aims to optimise localised drug delivery of a living bacterial strain. Various capsule shells, polymers and polymer combinations were assessed for physico-chemical and biorelevant properties, as well as bacterial viability. Pullulan capsules demonstrated superior mucoadhesive properties, and the formulation combining Carbomer and PEO emerged as optimal, offering sustained adhesion and viable bacterial delivery in simulated vaginal conditions. These findings underscore the potential of mucoadhesive LBPs in enhancing vaginal health through targeted, prolonged and biocompatible delivery systems.
Keywords
Capsules, Drug delivery, Live biotherapeutic products, Mucoadhesion, Polymers
Subject (DDC)
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ISBN
ISSN
0014-8237
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Future Health
Publication status
Published
Review
Peer review of the complete publication
Open access category
Closed
License
Citation
Aleksovski, A., Hosseini, H., Alkhafaji, H., Leite, M., Sagasta, A., Leopold, V., & Germershaus, O. (2025). Design and evaluation of mucoadhesive capsule formulations of live biotherapeutic product for vaginal delivery of lactobacillus SPP. Farmacia, 73(5), 1155–1163. https://doi.org/10.31925/farmacia.2025.5.9