Investigating additive effects on α-glycine growth through the measurement of facet specific growth rates
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Autor:in (Körperschaft)
Publikationsdatum
13.02.2025
Typ der Arbeit
Studiengang
Typ
01A - Beitrag in wissenschaftlicher Zeitschrift
Herausgeber:innen
Herausgeber:in (Körperschaft)
Betreuer:in
Übergeordnetes Werk
Crystal Growth & Design
Themenheft
DOI der Originalpublikation
Link
Zugehörige Forschungsdaten
Reihe / Serie
Reihennummer
Jahrgang / Band
25
Ausgabe / Nummer
5
Seiten / Dauer
Patentnummer
Verlag / Herausgebende Institution
American Chemical Society
Verlagsort / Veranstaltungsort
Auflage
Version
Programmiersprache
Abtretungsempfänger:in
Praxispartner:in/Auftraggeber:in
Zusammenfassung
The presence of trace amounts of additives during crystal growth can have a significant impact on the physical properties of the crystallizing substrate (e.g., crystal morphology, purity, polymorphic phase, or growth kinetics). In this work, we report the growth of α-glycine crystals (α-gly) in the presence of a variety of diverse additives: two l-amino acids, two organic acids, α-iminodiacetic acid, and two chloride salts. Growth rate data from imaging, together with analytical techniques such as X-ray photoelectron spectroscopy (XPS) and fluorescence microscopy, are used to observe which facet growth is impacted by the additive and to what extent. Relating these findings to the α-gly crystal structure provides explanations for the observed effects. Specifically, the growth inhibition of the (02̅0) facet α-gly in the presence of l-tryptophan and l-methionine shows how the prochirality of glycine results in two symmetrically equivalent facets growing at different rates. In the presence of malonic acid and salicylic acid, growth of the {011} facets is inhibited as a result of the interaction of deprotonated acids at the {011} surfaces. We find α-iminodiacetic acid to be an extremely effective inhibitor of α-gly, stopping the growth of both the {011} and {020} facets. We correlate the effectiveness of α-iminodiacetic acid to its structural similarity to gly, allowing it to easily block the growth of two α-gly facets. Finally, we observe the incorporation of the metal ions Fe(II), Cu(II), and Zn(II) into the {011} facets of α-gly. Interestingly, in the cases of Cu(II) and Zn(II), the incorporation of the metals into the α-gly lattice does not cause a noticeable change in the growth rates. The formation of coordination complexes containing the metal ions and glycine ligands allows for the observed incorporation of the metals into the α-gly lattice with limited disturbance to its crystal growth.
Schlagwörter
Additives, Crystallization, Crystals, Metals, Morphology
Fachgebiet (DDC)
Veranstaltung
Startdatum der Ausstellung
Enddatum der Ausstellung
Startdatum der Konferenz
Enddatum der Konferenz
Datum der letzten Prüfung
ISBN
ISSN
1528-7483
1528-7505
1528-7505
Sprache
Englisch
Während FHNW Zugehörigkeit erstellt
Nein
Zukunftsfelder FHNW
Publikationsstatus
Veröffentlicht
Begutachtung
Peer-Review der ganzen Publikation
Open Access-Status
Hybrid
Lizenz
Zitation
Offiler, C., Davey, R. J., Cruz-Cabeza, A. J., & Vetter, T. (2025). Investigating additive effects on α-glycine growth through the measurement of facet specific growth rates. Crystal Growth & Design, 25(5). https://doi.org/10.1021/acs.cgd.5c00028