Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine

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Autor:innen
Autor:in (Körperschaft)
Publikationsdatum
26.04.2016
Typ der Arbeit
Studiengang
Typ
01A - Beitrag in wissenschaftlicher Zeitschrift
Herausgeber:innen
Herausgeber:in (Körperschaft)
Betreuer:in
Übergeordnetes Werk
ACS Nano
Themenheft
DOI der Originalpublikation
Reihe / Serie
Reihennummer
Jahrgang / Band
10
Ausgabe / Nummer
4
Seiten / Dauer
3886-3899
Patentnummer
Verlag / Herausgebende Institution
American Chemical Society
Verlagsort / Veranstaltungsort
Auflage
Version
Programmiersprache
Abtretungsempfänger:in
Praxispartner:in/Auftraggeber:in
Zusammenfassung
Recent research has demonstrated that all body fluids assessed contain substantial amts. of vesicles that range in size from 30 to 1000 nm and that are surrounded by phospholipid membranes contg. different membrane microdomains such as lipid rafts and caveolae. The most prominent representatives of these so-​called extracellular vesicles (EVs) are nanosized exosomes (70-​150 nm)​, which are derivs. of the endosomal system, and microvesicles (100-​1000 nm)​, which are produced by outward budding of the plasma membrane. Nanosized EVs are released by almost all cell types and mediate targeted intercellular communication under physiol. and pathophysiol. conditions. Contg. cell-​type-​specific signatures, EVs have been proposed as biomarkers in a variety of diseases. Furthermore, according to their phys. functions, EVs of selected cell types have been used as therapeutic agents in immune therapy, vaccination trials, regenerative medicine, and drug delivery. Undoubtedly, the rapidly emerging field of basic and applied EV research will significantly influence the biomedicinal landscape in the future. In this Perspective, we, a network of European scientists from clin., academic, and industry settings collaborating through the H2020 European Cooperation in Science and Technol. (COST) program European Network on Microvesicles and Exosomes in Health and Disease (ME-​HAD)​, demonstrate the high potential of nanosized EVs for both diagnostic and therapeutic (i.e., theranostic) areas of nanomedicine.
Schlagwörter
extracellular vesicles, nanomedicine
Fachgebiet (DDC)
Projekt
Veranstaltung
Startdatum der Ausstellung
Enddatum der Ausstellung
Startdatum der Konferenz
Enddatum der Konferenz
Datum der letzten Prüfung
ISBN
ISSN
1936-0851
1936-086X
Sprache
Englisch
Während FHNW Zugehörigkeit erstellt
Ja
Publikationsstatus
Veröffentlicht
Begutachtung
Peer-Review der ganzen Publikation
Open Access-Status
Lizenz
Zitation
LIPPS, Georg, 2016. Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine. ACS Nano. 26 April 2016. Bd. 10, Nr. 4, S. 3886–3899. DOI 10.1021/acsnano.5b08015. Verfügbar unter: http://hdl.handle.net/11654/23404