Monitoring the particle size and shape in the crystallization of paracetamol from water
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Author (Corporation)
Publication date
04.2010
Type of student thesis
Course of study
Type
01A - Journal article
Editors
Editor (Corporation)
Supervisor
Parent work
Chemical Engineering Research and Design
Special issue
DOI of the original publication
Link
Related research data
Series
Series number
Volume
88
Issue / Number
4
Pages / Duration
447–454
Patent number
Publisher / Publishing institution
Elsevier
Place of publication / Event location
Edition
Version
Programming language
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Practice partner / Client
Abstract
In this work, a technique capable of restoring bidimensional particle size distributions from images of the particles in suspension is applied to the seeded cooling crystallization of paracetamol from water. The effects of cooling rate and stirring rate on the final particle size and shape are studied and the average growth rates along different directions of particles are found to be strongly dependend on supersaturation. This observation is in line with previous studies, though in this work it has been established for the first time using populations of particles. The technique was capable of quantifying changes in particle size and shape, indicating particle sizes and shapes that correlated well with observations from electron microscopy images. © 2009 The Institution of Chemical Engineers.
Keywords
Crystallization, Imaging, Instrumentation, Particle shape, Particle size, Particulate processes
Subject (DDC)
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ISBN
ISSN
0263-8762
1744-3563
1744-3563
Language
English
Created during FHNW affiliation
No
Strategic action fields FHNW
Publication status
Published
Review
peer-reviewed
Open access category
Closed
License
Citation
Kempkes, M., Vetter, T., & Mazzotti, M. (2010). Monitoring the particle size and shape in the crystallization of paracetamol from water. Chemical Engineering Research and Design, 88(4), 447–454. https://doi.org/10.1016/j.cherd.2009.09.006