Kidney-on-a-chip technology for drug-induced nephrotoxicity screening

dc.contributor.authorWilmer, Martijn J.
dc.contributor.authorNg, Chee Ping
dc.contributor.authorLanz, Henriëtte L.
dc.contributor.authorVulto, Paul
dc.contributor.authorSuter-Dick, Laura
dc.contributor.authorMasereeuw, Rosalinde
dc.date.accessioned2025-06-20T12:21:11Z
dc.date.issued2016-02
dc.description.abstractImproved model systems to predict drug efficacy, interactions, and drug induced kidney injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a suitable in vitro system because it reproduces the 3D microenvironment. A kidney-on-a-chip can mimic the structural, mechanical, transport, absorptive, and physiological properties of the human kidney. In this review we address the application of state-of-the-art microfluidic culturing techniques, with a focus on culturing kidney proximal tubules, that are promising for the detection of biomarkers that predict drug interactions and DIKI. We also discuss high-throughput screening and the challenges for in vitro to in vivo extrapolation (IVIVE) that will need to be overcome for successful implementation.
dc.identifier.doi10.1016/j.tibtech.2015.11.001
dc.identifier.issn0167-7799
dc.identifier.issn1879-3096
dc.identifier.urihttps://irf.fhnw.ch/handle/11654/51763
dc.issue2
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofTrends in Biotechnology
dc.subjectOrgan-on-a-chip
dc.subjectNephrotoxicity
dc.subjectDrug screening
dc.subjectMicrofluidics
dc.subjectHigh-throughput screening
dc.subjectKidney
dc.subject.ddc600 - Technik, Medizin, angewandte Wissenschaften
dc.titleKidney-on-a-chip technology for drug-induced nephrotoxicity screening
dc.type01A - Beitrag in wissenschaftlicher Zeitschrift
dc.volume34
dspace.entity.typePublication
fhnw.InventedHereYes
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.affiliation.hochschuleHochschule für Life Sciences FHNWde_CH
fhnw.affiliation.institutInstitut für Chemie und Bioanalytikde_CH
fhnw.openAccessCategoryClosed
fhnw.pagination156-170
fhnw.publicationStatePublished
fhnw.strategicActionFieldFuture Health
relation.isAuthorOfPublication37292405-e311-4093-a2e7-9a72a2511114
relation.isAuthorOfPublication.latestForDiscovery37292405-e311-4093-a2e7-9a72a2511114
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