Kidney-on-a-chip technology for drug-induced nephrotoxicity screening
dc.contributor.author | Wilmer, Martijn J. | |
dc.contributor.author | Ng, Chee Ping | |
dc.contributor.author | Lanz, Henriëtte L. | |
dc.contributor.author | Vulto, Paul | |
dc.contributor.author | Suter-Dick, Laura | |
dc.contributor.author | Masereeuw, Rosalinde | |
dc.date.accessioned | 2025-06-20T12:21:11Z | |
dc.date.issued | 2016-02 | |
dc.description.abstract | Improved model systems to predict drug efficacy, interactions, and drug induced kidney injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a suitable in vitro system because it reproduces the 3D microenvironment. A kidney-on-a-chip can mimic the structural, mechanical, transport, absorptive, and physiological properties of the human kidney. In this review we address the application of state-of-the-art microfluidic culturing techniques, with a focus on culturing kidney proximal tubules, that are promising for the detection of biomarkers that predict drug interactions and DIKI. We also discuss high-throughput screening and the challenges for in vitro to in vivo extrapolation (IVIVE) that will need to be overcome for successful implementation. | |
dc.identifier.doi | 10.1016/j.tibtech.2015.11.001 | |
dc.identifier.issn | 0167-7799 | |
dc.identifier.issn | 1879-3096 | |
dc.identifier.uri | https://irf.fhnw.ch/handle/11654/51763 | |
dc.issue | 2 | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.relation.ispartof | Trends in Biotechnology | |
dc.subject | Organ-on-a-chip | |
dc.subject | Nephrotoxicity | |
dc.subject | Drug screening | |
dc.subject | Microfluidics | |
dc.subject | High-throughput screening | |
dc.subject | Kidney | |
dc.subject.ddc | 600 - Technik, Medizin, angewandte Wissenschaften | |
dc.title | Kidney-on-a-chip technology for drug-induced nephrotoxicity screening | |
dc.type | 01A - Beitrag in wissenschaftlicher Zeitschrift | |
dc.volume | 34 | |
dspace.entity.type | Publication | |
fhnw.InventedHere | Yes | |
fhnw.ReviewType | Anonymous ex ante peer review of a complete publication | |
fhnw.affiliation.hochschule | Hochschule für Life Sciences FHNW | de_CH |
fhnw.affiliation.institut | Institut für Chemie und Bioanalytik | de_CH |
fhnw.openAccessCategory | Closed | |
fhnw.pagination | 156-170 | |
fhnw.publicationState | Published | |
fhnw.strategicActionField | Future Health | |
relation.isAuthorOfPublication | 37292405-e311-4093-a2e7-9a72a2511114 | |
relation.isAuthorOfPublication.latestForDiscovery | 37292405-e311-4093-a2e7-9a72a2511114 |
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