Mechanical characteristics of beta sheet-forming peptide hydrogels are dependent on peptide sequence, concentration and buffer composition
dc.accessRights | Anonymous | |
dc.audience | Science | |
dc.contributor.author | Koch, Franziska | |
dc.contributor.author | König, Finja | |
dc.contributor.author | Meyer, Nina | |
dc.contributor.author | Gattlen, Jasmin | |
dc.contributor.author | Pieles, Uwe | |
dc.contributor.author | Peters, Kirsten | |
dc.contributor.author | Kreikemeyer, Bernd | |
dc.contributor.author | Mathes, Stephanie | |
dc.contributor.author | Saxer, Sina | |
dc.contributor.author | Müller, Michael | |
dc.date.accessioned | 2018-12-13T09:51:36Z | |
dc.date.available | 2018-12-13T09:51:36Z | |
dc.date.issued | 2018-03 | |
dc.description.abstract | Self-assembling peptide hydrogels can be modified regarding their biodegradability, their chemical and mechanical properties and their nanofibrillar structure. Thus, self-assembling peptide hydrogels might be suitable scaffolds for regenerative therapies and tissue engineering. Owing to the use of various peptide concentrations and buffer compositions, the self-assembling peptide hydrogels might be influenced regarding their mechanical characteristics. Therefore, the mechanical properties and stability of a set of self-assembling peptide hydrogels, consisting of 11 amino acids, made from four beta sheet self-assembling peptides in various peptide concentrations and buffer compositions were studied. The formed self-assembling peptide hydrogels exhibited stiffnesses ranging from 0.6 to 205 kPa. The hydrogel stiffness was mostly affected by peptide sequence followed by peptide concentration and buffer composition. All self-assembling peptide hydrogels examined provided a nanofibrillar network formation. A maximum self-assembling peptide hydrogel dissolution of 20% was observed for different buffer solutions after 7 days. The stability regarding enzymatic and bacterial digestion showed less degradation in comparison to the self-assembling peptide hydrogel dissolution rate in buffer. The tested set of self-assembling peptide hydrogels were able to form stable scaffolds and provided a broad spectrum of tissue-specific stiffnesses that are suitable for a regenerative therapy. | |
dc.identifier.doi | 10.1098/rsos.171562 | |
dc.identifier.issn | 2054-5703 | |
dc.identifier.uri | http://hdl.handle.net/11654/26948 | |
dc.language.iso | en | en_US |
dc.publisher | Royal Society | en_US |
dc.relation.ispartof | Royal Society Open Science | en_US |
dc.subject | self-assembling peptides (SAP) | |
dc.subject | SAP hydrogel stiffness | |
dc.subject | nanofibrillar architectur | |
dc.subject | SAP hydrogel degrability | |
dc.title | Mechanical characteristics of beta sheet-forming peptide hydrogels are dependent on peptide sequence, concentration and buffer composition | |
dc.type | 01A - Beitrag in wissenschaftlicher Zeitschrift | |
dspace.entity.type | Publication | |
fhnw.InventedHere | Yes | |
fhnw.IsStudentsWork | no | |
fhnw.PublishedSwitzerland | No | |
fhnw.ReviewType | Anonymous ex ante peer review of a complete publication | |
fhnw.affiliation.hochschule | Hochschule für Life Sciences FHNW | de_CH |
fhnw.affiliation.institut | Institut für Chemie und Bioanalytik | de_CH |
fhnw.publicationOnline | Ja | |
fhnw.publicationState | Published | |
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relation.isAuthorOfPublication.latestForDiscovery | 62f9c87a-a655-482a-a9b4-56720f9d607d |