Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs – a PEARRL review

dc.accessRightsAnonymous
dc.audienceScience
dc.contributor.authorJankovic, Sandra
dc.contributor.authorTsakiridou, Georgia
dc.contributor.authorDitzinger, Felix
dc.contributor.authorKoehl, Niklas
dc.contributor.authorPrice, Daniel
dc.contributor.authorIlie, Alexandra Roxana
dc.contributor.authorKalantzi, Lida
dc.contributor.authorKimpe, Kristof
dc.contributor.authorHolm, Rene
dc.contributor.authorNair, Anita
dc.contributor.authorGriffin, Brendan
dc.contributor.authorSaal, Christoph
dc.contributor.authorKuentz, Martin
dc.date.accessioned2019-01-25T08:27:50Z
dc.date.available2019-01-25T08:27:50Z
dc.date.issued2018-07
dc.description.abstractObjectives Solubility parameters have been used for decades in various scientific fields including pharmaceutics. It is, however, still a field of active research both on a conceptual and experimental level. This work addresses the need to review solubility parameter applications in pharmaceutics of poorly water‐soluble drugs. Key findings An overview of the different experimental and calculation methods to determine solubility parameters is provided, which covers from classical to modern approaches. In the pharmaceutical field, solubility parameters are primarily used to guide organic solvent selection, cocrystals and salt screening, lipid‐based delivery, solid dispersions and nano‐ or microparticulate drug delivery systems. Solubility parameters have been applied for a quantitative assessment of mixtures, or they are simply used to rank excipients for a given drug. Summary In particular, partial solubility parameters hold great promise for aiding the development of poorly soluble drug delivery systems. This is particularly true in early‐stage development, where compound availability and resources are limited. The experimental determination of solubility parameters has its merits despite being rather labour‐intensive because further data can be used to continuously improve in silico predictions. Such improvements will ensure that solubility parameters will also in future guide scientists in finding suitable drug formulations.
dc.description.urihttps://onlinelibrary.wiley.com/doi/full/10.1111/jphp.12948
dc.identifier.doihttps://doi.org/10.1111/jphp.12948
dc.identifier.issn0022-3573
dc.identifier.issn2042-7158
dc.identifier.urihttp://hdl.handle.net/11654/27329
dc.identifier.urihttp://dx.doi.org/10.26041/fhnw-1640
dc.issue4
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Pharmacy and Pharmacologyen_US
dc.subjectenabling formulation
dc.subjectin silico prediction
dc.subjectpoorly water-soluble drug
dc.subjectsolubility parameter
dc.titleApplication of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs – a PEARRL review
dc.type01A - Beitrag in wissenschaftlicher Zeitschrift
dc.volume71
dspace.entity.typePublication
fhnw.InventedHereYes
fhnw.IsStudentsWorkno
fhnw.PublishedSwitzerlandNo
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.affiliation.hochschuleHochschule für Life Sciencesde_CH
fhnw.affiliation.institutInstitut für Pharma Technologyde_CH
fhnw.publicationOnlineJa
fhnw.publicationStatePublished
relation.isAuthorOfPublicationd778ae33-3c34-42ae-8445-343e2c0753c3
relation.isAuthorOfPublicationc98cfb03-0873-44b0-9b19-e4193630a183
relation.isAuthorOfPublication68819448-8611-488b-87bc-1b1cf9a6a1b4
relation.isAuthorOfPublication.latestForDiscovery68819448-8611-488b-87bc-1b1cf9a6a1b4
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