Hydrophobic deep eutectic solvent (HDES) as oil phase in lipid-based drug formulations
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Author (Corporation)
Publication date
15.08.2024
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Type
01A - Journal article
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Parent work
International Journal of Pharmaceutics
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Volume
661
Issue / Number
Pages / Duration
124418
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Publisher / Publishing institution
Elsevier
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Abstract
There is increasing pharmaceutical interest in deep eutectic solvents not only as a green alternative to organic solvents in drug manufacturing, but also as liquid formulation for drug delivery. The present work introduces a hydrophobic deep eutectic solvent (HDES) to the field of lipid-based formulations (LBF). Phase behavior of a mixture with 2:1 M ratio of decanoic- to dodecanoic acid was studied experimentally and described by thermodynamic modelling. Venetoclax was selected as a hydrophobic model drug and studied by atomistic molecular dynamics simulations of the mixtures. As a result, valuable molecular insights were gained into the interaction networks between the different components. Moreover, experimentally the HDES showed greatly enhanced drug solubilization compared to conventional glyceride-based vehicles, but aqueous dispersion behavior was limited. Hence surfactants were studied for their ability to improve aqueous dispersion and addition of Tween 80 resulted in lowest droplet sizes and high in vitro drug release. In conclusion, the combination of HDES with surfactant(s) provides a novel LBF with high pharmaceutical potential. However, the components must be finely balanced to keep the integrity of the solubilizing HDES, while enabling sufficient dispersion and drug release.
Keywords
Deep eutectic solvent(s), Eutectic(s), Poorly soluble drug(s), Lipid-based formulation(s), Novel pharmaceutic(s), Advanced formulation(s)
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ISBN
ISSN
0378-5173
1873-3476
1873-3476
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Hybrid
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Citation
Panbachi, S., Beranek, J., & Kuentz, M. (2024). Hydrophobic deep eutectic solvent (HDES) as oil phase in lipid-based drug formulations. International Journal of Pharmaceutics, 661, 124418. https://doi.org/10.1016/j.ijpharm.2024.124418