Temperature-Induced Surface Effects on Drug Nanosuspensions
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Authors
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Publication date
02/2018
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Type
01A - Journal article
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Parent work
Pharmaceutical Research
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Volume
35
Issue / Number
69
Pages / Duration
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Publisher / Publishing institution
Springer
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Abstract
Purpose
The trial-and-error approach is still predominantly used in pharmaceutical development of nanosuspensions. Physicochemical dispersion stability is a primary focus and therefore, various analytical bulk methods are commonly employed. Clearly less attention is directed to surface changes of nanoparticles even though such interface effects can be of pharmaceutical relevance. Such potential effects in drug nanosuspensions were to be studied for temperatures of 25 and 37°C by using complementary surface analytical methods.
Methods
Atomic force microscopy, inverse gas chromatography and UV surface dissolution imaging were used together for the first time to assess pharmaceutical nanosuspensions that were obtained by wet milling. Fenofibrate and bezafibrate were selected as model drugs in presence of sodium dodecyl sulfate and hydroxypropyl cellulose as anionic and steric stabilizer, respectively.
Results
It was demonstrated that in case of bezafibrate nanosuspension, a surface modification occurred at 37°C compared to 25°C, which notably affected dissolution rate. By contrast, no similar effect was observed in case of fenofibrate nanoparticles.
Conclusions
The combined usage of analytical surface methods provides the basis for a better understanding of phenomena that take place on drug surfaces. Such understanding is of importance for pharmaceutical development to achieve desirable quality attributes of nanosuspensions.
Keywords
atomic force microscopy, nanosuspension, surface characterization, surface dissolution, wet-milling
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ISBN
ISSN
0724-8741
1573-904X
1573-904X
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
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Peer review of the complete publication
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Citation
Aleandri, S., Schönenberger, M., Niederquell, A., & Kuentz, M. (2018). Temperature-Induced Surface Effects on Drug Nanosuspensions. Pharmaceutical Research, 35(69). https://doi.org/10.1007/s11095-017-2300-6