Dynamic patterns of global brain communication differentiate conscious from unconscious patients after severe brain injury
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Dateien
Autor:innen
Golkowski, Daniel
Willnecker, Rebecca
Rösler, Jennifer
Ranft, Andreas
Schneider, Gerhard
Ilg, Rüdiger
Autor:in (Körperschaft)
Publikationsdatum
2021
Typ der Arbeit
Studiengang
Sammlung
Typ
01A - Beitrag in wissenschaftlicher Zeitschrift
Herausgeber:innen
Herausgeber:in (Körperschaft)
Betreuer:in
Übergeordnetes Werk
Frontiers in Systems Neuroscience
Themenheft
DOI der Originalpublikation
Link
Reihe / Serie
Reihennummer
Jahrgang / Band
15
Ausgabe / Nummer
Seiten / Dauer
Patentnummer
Verlag / Herausgebende Institution
Frontiers Research Foundation
Verlagsort / Veranstaltungsort
Auflage
Version
Programmiersprache
Abtretungsempfänger:in
Praxispartner:in/Auftraggeber:in
Zusammenfassung
The neurophysiology of the subjective sensation of being conscious is elusive; therefore, it remains controversial how consciousness can be recognized in patients who are not responsive but seemingly awake. During general anesthesia, a model for the transition between consciousness and unconsciousness, specific covariance matrices between the activity of brain regions that we call patterns of global brain communication reliably disappear when people lose consciousness. This functional magnetic imaging study investigates how patterns of global brain communication relate to consciousness and unconsciousness in a heterogeneous sample during general anesthesia and after brain injury. First, we describe specific patterns of global brain communication during wakefulness that disappear during propofol and sevoflurane general anesthesia. Second, we search for these patterns in a cohort of unresponsive wakeful patients and unmatched healthy controls in order to evaluate their potential use in clinical practice. We found that patterns of global brain communication characterized by high covariance in sensory and motor areas or low overall covariance and their dynamic change were strictly associated with intact consciousness in this cohort. In addition, we show that the occurrence of these two patterns is significantly related to activity within the frontoparietal network of the brain, a network known to play a crucial role in conscious perception. We propose that this approach potentially recognizes consciousness in the clinical routine setting.
Schlagwörter
Consciousness, Brain injury, Coma, Unresponsive wakefulness syndrome, fMRI, Anesthesia, Propofol, Sevoflurane
Fachgebiet (DDC)
600 - Technik, Medizin, angewandte Wissenschaften
Veranstaltung
Startdatum der Ausstellung
Enddatum der Ausstellung
Startdatum der Konferenz
Enddatum der Konferenz
Datum der letzten Prüfung
ISBN
ISSN
1662-5137
Sprache
Englisch
Während FHNW Zugehörigkeit erstellt
Ja
Zukunftsfelder FHNW
Publikationsstatus
Veröffentlicht
Begutachtung
Peer-Review der ganzen Publikation
Open Access-Status
Gold
Lizenz
Zitation
GOLKOWSKI, Daniel, Rebecca WILLNECKER, Jennifer RÖSLER, Andreas RANFT, Gerhard SCHNEIDER, Denis JORDAN und Rüdiger ILG, 2021. Dynamic patterns of global brain communication differentiate conscious from unconscious patients after severe brain injury. Frontiers in Systems Neuroscience. 2021. Bd. 15. DOI 10.3389/fnsys.2021.625919. Verfügbar unter: https://doi.org/10.26041/fhnw-9494