Solubility of 5-aminosalicylic acid in N-methyl-2-pyrrolidone + water mixtures at various temperatures
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Authors
Jouyban, Kimia
Author (Corporation)
Publication date
19.04.2020
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Type
01A - Journal article
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Supervisor
Parent work
Journal of Molecular Liquids
Special issue
DOI of the original publication
Series
Series number
Volume
310
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Pages / Duration
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Publisher / Publishing institution
Elsevier
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Abstract
Drug solubility studies in solvent mixtures have great importance in the pharmaceutical sciences especially in pharmaceutical technology. Advancements in thermodynamic modeling enable a better mechanistic understanding and can provide guidance in the development of promising solvent mixtures for a given drug. This work studied equilibrium solubility of 5-aminosalicylic acid (mesalazine) in mixed solvents using N-methyl-2-pyrrolidone (NMP) and water at T = (293.2 to 313.2) K. The obtained solubility data were described mathematically by the van't Hoff, Jouyban-Acree, Jouyban-Acree-van't Hoff, UNIQUAC and NRTL models. To discuss the solute-solvent interactions, the activity coefficients of mesalazine were determined in the investigated mixtures. Calculation of the apparent thermodynamic properties of dissolution and mixing for mesalazine, as well as, the preferential solvation parameters in the studied mixtures provided valuable molecular insights into the studied model system and the results are of practical relevance in case of mesalazine.
Keywords
Solid-liquid equilibrium, Mesalazine, N-methyl-2-pyrrolidone, Activity coefficient, Preferential solvation
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ISBN
ISSN
0167-7322
1873-3166
1873-3166
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
License
Citation
Jouyban, K., & Kuentz, M. (2020). Solubility of 5-aminosalicylic acid in N-methyl-2-pyrrolidone + water mixtures at various temperatures. Journal of Molecular Liquids, 310. https://doi.org/10.1016/j.molliq.2020.113143