Solubility of 5-aminosalicylic acid in N-methyl-2-pyrrolidone + water mixtures at various temperatures

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Authors
Jouyban, Kimia
Author (Corporation)
Publication date
19.04.2020
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01A - Journal article
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Parent work
Journal of Molecular Liquids
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DOI of the original publication
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Volume
310
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Elsevier
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Abstract
Drug solubility studies in solvent mixtures have great importance in the pharmaceutical sciences especially in pharmaceutical technology. Advancements in thermodynamic modeling enable a better mechanistic understanding and can provide guidance in the development of promising solvent mixtures for a given drug. This work studied equilibrium solubility of 5-aminosalicylic acid (mesalazine) in mixed solvents using N-methyl-2-pyrrolidone (NMP) and water at T = (293.2 to 313.2) K. The obtained solubility data were described mathematically by the van't Hoff, Jouyban-Acree, Jouyban-Acree-van't Hoff, UNIQUAC and NRTL models. To discuss the solute-solvent interactions, the activity coefficients of mesalazine were determined in the investigated mixtures. Calculation of the apparent thermodynamic properties of dissolution and mixing for mesalazine, as well as, the preferential solvation parameters in the studied mixtures provided valuable molecular insights into the studied model system and the results are of practical relevance in case of mesalazine.
Keywords
Solid-liquid equilibrium, Mesalazine, N-methyl-2-pyrrolidone, Activity coefficient, Preferential solvation
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ISBN
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0167-7322
1873-3166
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
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Peer review of the complete publication
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Citation
Jouyban, K., & Kuentz, M. (2020). Solubility of 5-aminosalicylic acid in N-methyl-2-pyrrolidone + water mixtures at various temperatures. Journal of Molecular Liquids, 310. https://doi.org/10.1016/j.molliq.2020.113143