Fractal Aspects of Static and Dynamic Flow Properties of Pharmaceutical Excipients
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Authors
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Publication date
11/2017
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Type
01A - Journal article
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Parent work
Journal of Pharmaceutical Innovation
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Issue / Number
Pages / Duration
1-12
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Springer
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Abstract
Purpose
Characterisation of powder flow is important for pharmaceutical processing and manufacturing. This work aims at a better understanding of how fractal particle and bulk properties affect the static and dynamic flow of excipients.
Methods
Traditional methods of flowability testing, e.g. the angle of repose or the flow through an orifice, were complemented by avalanching in a rotational drum. Dynamic image analysis provided a fractal contour line dimension of the powder bulk in the drum (bD F ). This was compared to the contour line fractal dimension of particles (pD F ) as obtained from the box-counting method. Avalanche testing was able to measure also cohesive materials that were otherwise difficult or not measurable at all using the classical methods.
Results
The values of the avalanche energy were in good agreement with the different flow properties of the samples. These flow properties showed good correlations with bD F in that poor flow properties were associated with a more rugged contour line of the bulk and hence higher bD F .
Conclusions
Interestingly, there was no correlation observed between pD F and bD F , which may suggest that a distinct bulk structure typically emerges from the particles under dynamic flow. Future research should further clarify how fractal powder aspects affect pharmaceutical manufacturing processes.
Keywords
Flowability, Avalanching, Dynamic behaviour, Rotating drum, Particle fractal dimension, Bulk fractal dimension
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ISBN
ISSN
1872-5120
1939-8042
1939-8042
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
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License
Citation
Hurychová, H., Šklubalová, Z., & Kuentz, M. (2017). Fractal Aspects of Static and Dynamic Flow Properties of Pharmaceutical Excipients. Journal of Pharmaceutical Innovation, 1–12. https://doi.org/10.1007/s12247-017-9302-0