Molecularly designed lipid microdomains for solid dispersions using a polymer/inorganic carrier matrix produced by hot-melt extrusion

dc.accessRightsAnonymous
dc.audienceScience
dc.contributor.authorAdler, Camille
dc.contributor.authorSchönenberger, Monica
dc.contributor.authorTeleki, Alexandra
dc.contributor.authorKuentz, Martin
dc.date.accessioned2016-12-16T11:23:37Z
dc.date.available2016-12-16T11:23:37Z
dc.date.issued2016-02-29
dc.description.abstractAmorphous solid dispersions have for many years been a focus in oral formulations, especially in combination with a hot-melt extrusion process. The present work targets a novel approach with a system based on a fatty acid, a polymer and an inorganic carrier. It was intended to adsorb the acidic lipid by specific molecular interactions onto the solid carrier to design disorder in the alkyl chains of the lipid. Such designed lipid microdomains (DLM) were created as a new microstructure to accommodate a compound in a solid dispersion. Vibrational spectroscopy, X-ray powder diffraction, atomic force microscopy as well as electron microscopic imaging were employed to study a system of stearic acid, hydroxypropylcellulose and aluminum magnesium silicate. β-carotene was used as a poorly water-soluble model substance that is difficult to formulate with conventional solid dispersion formulations. The results indicated that the targeted molecular excipient interactions indeed led to DLMs for specific compositions. The different methods provided complementary aspects and important insights into the created microstructure. The novel delivery system appeared to be especially promising for the formulation of oral compounds that exhibit both high crystal energy and lipophilicity.
dc.identifier.doihttp://dx.doi.org/10.1016/j.ijpharm.2015.12.057
dc.identifier.issn0378-5173
dc.identifier.issn1873-3476
dc.identifier.urihttp://hdl.handle.net/11654/23745
dc.issue1-2
dc.language.isoenen
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Pharmaceuticsen_US
dc.subjectAcidic lipid
dc.subjectDesigned lipid microdomains
dc.subjectInorganic carrier
dc.subjectInteractions
dc.subjectHot-melt extrusion
dc.titleMolecularly designed lipid microdomains for solid dispersions using a polymer/inorganic carrier matrix produced by hot-melt extrusion
dc.type01A - Beitrag in wissenschaftlicher Zeitschrift
dc.volume499
dspace.entity.typePublication
fhnw.InventedHereYes
fhnw.IsStudentsWorkno
fhnw.PublishedSwitzerlandNo
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.affiliation.hochschuleHochschule für Life Sciencesde_CH
fhnw.affiliation.institutInstitut für Pharma Technologyde_CH
fhnw.pagination90-100
fhnw.publicationOnlineJa
fhnw.publicationStatePublished
relation.isAuthorOfPublication68819448-8611-488b-87bc-1b1cf9a6a1b4
relation.isAuthorOfPublication.latestForDiscovery68819448-8611-488b-87bc-1b1cf9a6a1b4
Dateien
Lizenzbündel
Gerade angezeigt 1 - 1 von 1
Lade...
Vorschaubild
Name:
license.txt
Größe:
2.94 KB
Format:
Item-specific license agreed upon to submission
Beschreibung: