Characterization of a cotton-wool like composite bone graft material
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Authors
Author (Corporation)
Publication date
18.07.2022
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Type
01A - Journal article
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Parent work
Journal of Materials Science: Materials in Medicine
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DOI of the original publication
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Volume
33
Issue / Number
8
Pages / Duration
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Springer
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Abstract
Bone graft materials are applied in patients to augment bone defects and enable the insertion of an implant in its ideal position. However, the currently available augmentation materials do not meet the requirements of being completely resorbed and replaced by new bone within 3 to 6 months. A novel electrospun cotton-wool like material (Bonewool, Zurich Biomaterials LLC, Zurich, Switzerland) consisting of biodegradable poly(lactic-co-glycolic) acid (PLGA) fibers with incorporated amorphous ß-tricalcium phosphate (ß-TCP) nanoparticles has been compared to a frequently used bovine derived hydroxyapatite (Bio-Oss, Geistlich Pharma, Wolhusen, Switzerland) in vitro. The material composition was determined and the degradation behavior (calcium release and pH in different solutions) as well as bioactivity has been measured. Degradation behavior of PLGA/ß-TCP was generally more progressive than for Bio-Oss, indicating that this material is potentially completely resorbable.
Keywords
Bonewool, bone augmentation, Bio-Oss, hydroxyapatite, tricalcium phosphate, PLGA
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ISBN
ISSN
1573-4838
0957-4530
0957-4530
Language
German
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Gold
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Citation
Rohr, N., Brunner, C., Bellon, B., Fischer, J., & de Wild, M. (2022). Characterization of a cotton-wool like composite bone graft material. Journal of Materials Science: Materials in Medicine, 33(8). https://doi.org/10.1007/s10856-022-06682-3