Residence time distribution characterization and proof-of-concept of a novel stacked 7-stage continuous crystallizer cascade with diaphragm-driven slurry transfer
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Author (Corporation)
Publication date
09.10.2024
Type of student thesis
Course of study
Type
01A - Journal article
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Parent work
Industrial & Engineering Chemistry Research
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Volume
63
Issue / Number
42
Pages / Duration
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Publisher / Publishing institution
American Chemical Society
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Abstract
Process developers in the pharmaceutical industry lack readily deployable, standardized, off-the-shelf continuous crystallizers (<100 mL), abiding the low material requirements of early stage product development. This study evaluates a novel continuous tower crystallizer (TWC), hosting a series of seven vertically stacked mixed suspension mixed product removal crystallizers (MSMPRCs, 80 mL total volume) enabled by an innovative diaphragm driven slurry transfer, which eliminates known transfer line issues in MSMPRC cascades. Residence time distribution measurements using the model compound glycine demonstrate ideal mixing for both liquid (homogeneous) and solid (heterogeneous) phases (particle < 100 μm, slurry density < 22.8%). A comparison with the tank in series model reveals nonideal mixing for particles >300 μm. Finally, a proof-of-concept continuous antisolvent crystallization of glycine demonstrates the TWC’s capability to produce high-quality crystals continuously, proving its functional and robust operation.
Keywords
Crystallization, Crystals, Liquids, Materials, Particle size
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ISBN
ISSN
0888-5885
1520-5045
1520-5045
Language
English
Created during FHNW affiliation
No
Strategic action fields FHNW
Publication status
Published
Review
peer-reviewed
Open access category
Closed
License
Citation
Aprile, G., Pandit, A. V., Albertazzi, J., Vetter, T., Viano, R., Milani, L., Adamo, A., Myerson, A. S., & Stelzer, T. (2024). Residence time distribution characterization and proof-of-concept of a novel stacked 7-stage continuous crystallizer cascade with diaphragm-driven slurry transfer. Industrial & Engineering Chemistry Research, 63(42). https://doi.org/10.1021/acs.iecr.4c02153