Partial Solvation Parameters of Drugs as a New Thermodynamic Tool for Pharmaceutics
Kein Vorschaubild vorhanden
Autor:innen
Autor:in (Körperschaft)
Publikationsdatum
04.01.2019
Typ der Arbeit
Studiengang
Sammlung
Typ
01A - Beitrag in wissenschaftlicher Zeitschrift
Herausgeber:innen
Herausgeber:in (Körperschaft)
Betreuer:in
Übergeordnetes Werk
Pharmaceutics
Themenheft
DOI der Originalpublikation
Reihe / Serie
Reihennummer
Jahrgang / Band
11
Ausgabe / Nummer
1
Seiten / Dauer
Patentnummer
Verlag / Herausgebende Institution
Elsevier
Verlagsort / Veranstaltungsort
Auflage
Version
Programmiersprache
Abtretungsempfänger:in
Praxispartner:in/Auftraggeber:in
Zusammenfassung
Partial solvation parameters (PSP) have much in common with the Hansen solubility parameter or with a linear solvation energy relationship (LSER), but there are advantages based on the sound thermodynamic basis. It is, therefore, surprising that PSP has so far not been harnessed in pharmaceutics for the selection of excipients or property estimation of formulations and their components. This work introduces PSP calculation for drugs, where the raw data were obtained from inverse gas chromatography. It was shown that only a few probe gases were needed to get reasonable estimates of the drug PSPs. Interestingly, an alternative calculation of LSER parameters in silico did not reflect the experimentally obtained activity coefficients for all probe gases as well, which was attributed to the complexity of the drug structures. The experimental PSPs were proven to be helpful in predicting drug solubility in various solvents and the PSP framework allowed calculation of the different surface energy contributions. A specific benefit of PSP is that parameters can be readily converted to either classical solubility or LSER parameters. Therefore, PSP is not just about a new definition of solvatochromic parameters, but the underlying thermodynamics provides a unified approach, which holds much promise for broad applications in pharmaceutics.
Schlagwörter
drug, partial solvation parameters, solubility, surface energy, thermodynamics
Fachgebiet (DDC)
Veranstaltung
Startdatum der Ausstellung
Enddatum der Ausstellung
Startdatum der Konferenz
Enddatum der Konferenz
Datum der letzten Prüfung
ISBN
ISSN
0378-5173
1873-3476
1873-3476
Sprache
Englisch
Während FHNW Zugehörigkeit erstellt
Ja
Zukunftsfelder FHNW
Publikationsstatus
Veröffentlicht
Begutachtung
Peer-Review der ganzen Publikation
Open Access-Status
Lizenz
Zitation
NIEDERQUELL, Andreas und Martin KUENTZ, 2019. Partial Solvation Parameters of Drugs as a New Thermodynamic Tool for Pharmaceutics. Pharmaceutics. 4 Januar 2019. Bd. 11, Nr. 1. DOI 10.3390/pharmaceutics11010017. Verfügbar unter: https://irf.fhnw.ch/handle/11654/30426