Predictors of fasting endogenous Erythritol and Erythronate concentrations in humans. cross-sectional and post-bariatric surgery analyses
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Author (Corporation)
Publication date
07.10.2025
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Type
01A - Journal article
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Parent work
International Journal of Molecular Sciences
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DOI of the original publication
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Volume
26
Issue / Number
19
Pages / Duration
9763
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Publisher / Publishing institution
MDPI
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Abstract
The sugar alcohol erythritol occurs naturally in fruits and fermented foods, is used as a sweetener, and is also endogenously synthesized via the pentose-phosphate pathway and metabolized into erythronate. Untargeted metabolomic studies have associated elevated plasma erythritol and erythronate concentrations with metabolic disorders, while weight loss has been linked to decreased plasma erythritol concentrations. In this trial, two complementary analyses were performed to identify predictors of fasting erythritol and erythronate concentrations across different populations and to assess changes in these metabolites following bariatric surgery-induced weight loss. Fasting plasma samples from 30 lean adolescents, 50 lean adults, and 138 adults with obesity (including 15 who had undergone bariatric surgery) were analyzed to measure erythritol, erythronate, glucose, and insulin concentrations. Across all populations, age but not body mass index (BMI), glucose, or insulin, was a significant predictor of fasting erythritol concentrations. Fasting erythronate concentrations were associated with both age and BMI. Post-surgery, change in BMI but not fasting glucose or insulin was a predictor of changes in fasting erythritol concentrations, while time was the only predictor of changes in fasting erythronate concentrations. Although the metabolic processes regulating the endogenous erythritol and erythronate production remain unclear, our findings suggest that age-related physiological
changes may influence fasting concentrations of both erythritol and erythronate.
Keywords
Erythritol, Erythronate, Endogenous, Bariatric surgery
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ISBN
ISSN
1422-0067
1661-6596
1661-6596
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Gold
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Citation
Flad, E., Altstädt, A., Drewe, J., Gaugler, S., Beglinger, C., Peterli, R., Wölnerhanssen, B. K., & Meyer-Gerspach, A. C. (2025). Predictors of fasting endogenous Erythritol and Erythronate concentrations in humans. cross-sectional and post-bariatric surgery analyses. International Journal of Molecular Sciences, 26(19), 9763. https://doi.org/10.3390/ijms26199763