Influence of cannabis use on incidence of psychosis in people at clinical high risk

Aims Evidence for case–control studies suggests that cannabis use is a risk factor for the development of psychosis. However, there have been limited prospective studies and the direction of this association remains controversial. The primary aim of the present study was to examine the association between cannabis use and the incidence of psychotic disorders in people at clinical high risk of psychosis. Secondary aims were to assess associations between cannabis use and the persistence of psychotic symptoms, and with functional outcome. Methods Current and previous cannabis use were assessed in individuals at clinical high risk of psychosis (n = 334) and healthy controls (n = 67), using a modified version of the Cannabis Experience Questionnaire. Participants were assessed at baseline and followed up for 2 years. Transition to psychosis and persistence of psychotic symptoms were assessed using the Comprehensive Assessment of At-Risk Mental States criteria. Level of functioning at follow up was assessed using the Global Assessment of Functioning disability scale. Results During follow up, 16.2% of the clinical high-risk sample developed psychosis. Of those who did not become psychotic, 51.4% had persistent symptoms and 48.6% were in remission. There was no significant association between any measure of cannabis use at baseline and either transition to psychosis, the persistence of symptoms, or functional outcome. Conclusions These findings contrast with epidemiological data that suggest that cannabis use increases the risk of psychotic disorder.

Schlagwörter

Fachgebiet (DDC)

330 - Wirtschaft

Projekt

Veranstaltung

Startdatum der Ausstellung

Enddatum der Ausstellung

Startdatum der Konferenz

Enddatum der Konferenz

Datum der letzten Prüfung

ISBN

ISSN

1440-1819
1323-1316

Sprache

Englisch

Während FHNW Zugehörigkeit erstellt

Ja

Zukunftsfelder FHNW

Publikationsstatus

Veröffentlicht

Begutachtung

Peer-Review der ganzen Publikation

Open Access-Status

Hybrid

Lizenz

Zitation

CHESTER, Lucy Ann, Lucia VALMAGGIA, Matthew KEMPTON, Edward CHESNEY, Dominic OLIVER, Emily HEDGES, Elise KLATSA, Daniel STAHL, Mark VAN DER GAAG, Lieuwe DE HAAN, Barnaby NELSON, Patrick MCGORRY, G. Paul AMMINGER, Anita RIECHER-RÖSSLER, Erich STUDERUS, Rodrigo BRESSAN, Neus BARRANTES-VIDAL, Marie-Odile KREBS, Birte GLENTHØJ, Merete NORDENTOFT, Stephan RUHRMANN, Gabriele SACHS und Philip MCGUIRE, 2023. Influence of cannabis use on incidence of psychosis in people at clinical high risk. Psychiatry and Clinical Neurosciences. 2023. Bd. 77, Nr. 9, S. 469–477. DOI 10.1111/pcn.13555. Verfügbar unter: https://doi.org/10.26041/fhnw-7463

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