SARS-CoV-2 variants of concern and clinical severity in the mexican pediatric population
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Dateien
Autor:innen
Maldonado-Cabrera, Anahí
Colin-Vilchis, Jesus Alejandro
Haque, Ubydul
Velazquez, Carlos
Alvarez Villaseñor, Andrea Socorro
Magdaleno-Márquez, Luis Eduardo
Calleros-Muñoz, Carlos Iván
Figueroa-Enríquez, Karen Fernanda
Gallego-Hernández, Ana Lucía
Autor:in (Körperschaft)
Publikationsdatum
2023
Typ der Arbeit
Studiengang
Typ
01A - Beitrag in wissenschaftlicher Zeitschrift
Herausgeber:innen
Herausgeber:in (Körperschaft)
Betreuer:in
Übergeordnetes Werk
Infectious Disease Reports
Themenheft
DOI der Originalpublikation
Link
Reihe / Serie
Reihennummer
Jahrgang / Band
15
Ausgabe / Nummer
5
Seiten / Dauer
535-548
Patentnummer
Verlag / Herausgebende Institution
MDPI
Verlagsort / Veranstaltungsort
Auflage
Version
Programmiersprache
Abtretungsempfänger:in
Praxispartner:in/Auftraggeber:in
Zusammenfassung
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VOCs) presents global heterogeneity, and their relative effect on pediatric severity is still limited. In this study, we associate VOCs with pediatric clinical severity outcomes in Mexico. Bioinformatics methods were used to characterize VOCs and single amino acid (aa) mutations in 75,348 SARS-CoV-2 genetic sequences from February 2020 to October 2022. High-predominance VOCs groups were calculated and subsequently associated with 372,989 COVID-19 clinical pediatric outcomes. We identified 21 high-frequency mutations related to Omicron lineages with an increased prevalence in pediatric sequences compared to adults. Alpha and the other lineages had a significant increase in case fatality rate (CFR), intensive critical unit (ICU) admission, and automated mechanical ventilation (AMV). Furthermore, a logistic model with age-adjusted variables estimated an increased risk of hospitalization, ICU/AMV, and death in Gamma and Alpha, in contrast to the other lineages. We found that, regardless of the VOCs lineage, infant patients presented the worst severity prognoses. Our findings improve the understanding of the impact of VOCs on pediatric patients across time, regions, and clinical outcomes. Enhanced understanding of the pediatric severity for VOCs would enable the development and improvement of public health strategies worldwide.
Schlagwörter
COVID-19, Children, Hospitalization, Mortality
Fachgebiet (DDC)
600 - Technik, Medizin, angewandte Wissenschaften
Veranstaltung
Startdatum der Ausstellung
Enddatum der Ausstellung
Startdatum der Konferenz
Enddatum der Konferenz
Datum der letzten Prüfung
ISBN
ISSN
2036-7449
Sprache
Englisch
Während FHNW Zugehörigkeit erstellt
Ja
Publikationsstatus
Veröffentlicht
Begutachtung
Peer-Review der ganzen Publikation
Open Access-Status
Gold
Lizenz
Zitation
MALDONADO-CABRERA, Anahí, Jesus Alejandro COLIN-VILCHIS, Ubydul HAQUE, Carlos VELAZQUEZ, Andrea Socorro ALVAREZ VILLASEÑOR, Luis Eduardo MAGDALENO-MÁRQUEZ, Carlos Iván CALLEROS-MUÑOZ, Karen Fernanda FIGUEROA-ENRÍQUEZ, Aracely ANGULO-MOLINA und Ana Lucía GALLEGO-HERNÁNDEZ, 2023. SARS-CoV-2 variants of concern and clinical severity in the mexican pediatric population. Infectious Disease Reports. 2023. Bd. 15, Nr. 5, S. 535–548. DOI 10.3390/idr15050053. Verfügbar unter: https://doi.org/10.26041/fhnw-7935