Multifractal and mechanical analysis of amorphous solid dispersions
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Authors
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Publication date
2017
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Type
01A - Journal article
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Parent work
International Journal of Pharmaceutics
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DOI of the original publication
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Series
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Volume
523
Issue / Number
1
Pages / Duration
91-101
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Publisher / Publishing institution
Elsevier
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Abstract
The formulation of lipophilic and hydrophobic compounds is a challenge for the pharmaceutical industry and it requires the development of complex formulations. Our first aim was to investigate hot-melt extrudate microstructures by means of multifractal analysis using scanning electron microscopy imaging. Since the microstructure can affect solid dosage form performance such as mechanical properties, a second objective was to study the influence of the type of adsorbent and of the presence of an amorphous compound on extrudate hardness. β-Carotene (BC) was chosen as poorly water-soluble model compound. Formulations containing a polymer, a lipid and two different silica based inorganic carriers were produced by hot-melt extrusion. Based on scanning electron microscopy/energy dispersive X-ray spectroscopy, the obtained images were analyzed using multifractal formalism. The breaking force of the strands was assessed by a three point bending test. Multifractal analysis and three point bending results showed that the nature of interparticle interactions in the inorganic carrier as well as the presence of amorphous BC had an influence on the microstructure and thus on the mechanical performance. The use of multifractal analysis and the study of the mechanical properties were complementary to better characterize and understand complex formulations obtained by hot-melt extrusion.
Keywords
Hot-melt extrusion, Solid dispersion, Inorganic carrier, Scanning electron microscopy, Multifractal Mechanical properties
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ISBN
ISSN
0378-5173
1873-3476
1873-3476
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
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Peer review of the complete publication
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Citation
Adler, C., Kuentz, M., & Teleki, A. (2017). Multifractal and mechanical analysis of amorphous solid dispersions. International Journal of Pharmaceutics, 523(1), 91–101. https://doi.org/10.1016/j.ijpharm.2017.03.014