Development of a unique rapid test to detect anti-bodies directed against an extended RBD of SARS-CoV-2 spike protein

dc.accessRightsAnonymous*
dc.contributor.authorBrosi, Larissa
dc.contributor.authorVilliger, Thomas
dc.contributor.authorBantleon, Frank
dc.contributor.authorMelone, Anna
dc.contributor.authorÜberschlag, Marie-Eve
dc.contributor.authorDolce, Daniele
dc.contributor.authorGiegelmann, Cedric
dc.contributor.authorGerspach, Michael
dc.contributor.authorDirscherl, Lorin
dc.contributor.authorPanikulam, Sherin
dc.contributor.authorRomann, Patrick
dc.contributor.authorWeston, Anna
dc.contributor.authorKübler, Eric
dc.contributor.authorGerhold, Christian
dc.date.accessioned2022-03-25T15:00:43Z
dc.date.available2022-03-25T15:00:43Z
dc.date.issued2021-05-28
dc.description.abstractSerological testing for antibodies directed against SARS-CoV-2 in patients may serve as a diagnostic tool to verify a previous infection and as surrogate for an elicited humoral immune response, ideally conferring immunity after infection or vaccination. Here, we present the recombinant expression of an extended receptor binding domain (RBD) of the SARS-CoV-2 Spike protein used as capture antigen in a unique rapid immunoassay to detect the presence of RBD binding antibodies with high sensitivity and specificity. As currently available vaccines focus on the Spike RBD as target, the developed test can also be used to monitor a successful immune response after vaccination with an RBD based vaccine.en_US
dc.identifier.doi10.2533/chimia.2021.446
dc.identifier.issn2673-2424
dc.identifier.issn0009-4293
dc.identifier.urihttps://irf.fhnw.ch/handle/11654/33390
dc.identifier.urihttps://doi.org/10.26041/fhnw-4142
dc.issue5en_US
dc.language.isoen_USen_US
dc.publisherSchweizerische Chemische Gesellschaften_US
dc.relation.ispartofChimiaen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/en_US
dc.spatialBernen_US
dc.subjectAntibodiesen_US
dc.subjectLateral flow assayen_US
dc.subjectPoint-of-careen_US
dc.subjectRbden_US
dc.subjectSars-cov-2en_US
dc.titleDevelopment of a unique rapid test to detect anti-bodies directed against an extended RBD of SARS-CoV-2 spike proteinen_US
dc.type01A - Beitrag in wissenschaftlicher Zeitschrift
dc.volume75en_US
dspace.entity.typePublication
fhnw.InventedHereYesen_US
fhnw.IsStudentsWorknoen_US
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publicationen_US
fhnw.affiliation.hochschuleHochschule für Life Sciences FHNWde_CH
fhnw.affiliation.institutInstitut für Chemie und Bioanalytikde_CH
fhnw.openAccessCategoryGolden_US
fhnw.pagination446-452en_US
fhnw.publicationStatePublisheden_US
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relation.isAuthorOfPublication0cf4631c-3059-42d5-9fbb-8fb2524d963d
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relation.isAuthorOfPublication.latestForDiscovery75b72169-64d8-4e5c-9fce-ffe0de0b00fc
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